18 Result(s)
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Chapter
Harinder Gill
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Chapter
Role of IDH1/IDH2 Inhibitors in AML
Mitochondrial activity is fundamental to supporting cellular metabolisms of almost all types of body cells. This carries paramount significance for the treatment of AML due to the presence of mitochondrial abn...
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Frontline Management of Acute Promyelocytic Leukemia
In the frontline management of acute promyelocytic leukemia (APL), prevention of early deaths and the selection of the optimal frontline induction strategies incorporating arsenic trioxide (ATO) and all-trans ...
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Management of Relapsed or Refractory AML
Standard induction chemotherapy for acute myeloid leukemia (AML) results in a remission rate of around 70%. Up to 30% of patients do not achieve a remission and approximately 50% of patients who achieve comple...
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Prognostic Models for Primary and Secondary Myelofibrosis
Although patients with primary and secondary myelofibrosis are at risk of disease progression into acute myeloid leukemia, they are heterogenous at presentation and have a highly variable survival. In the last...
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Next-Generation FLT3 Inhibitors for the Treatment of FLT3-Positive AML
Tyrosine kinases regulate a wide range of cellular pathways and are crucial to signal transduction. Their aberrant activities can contribute to leukaemogenesis via promoting proliferation, impeding differentia...
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Management of Relapsed Acute Promyelocytic Leukemia and the Role of Hematopoietic Stem Cell Transplantation
This chapter addresses one of the most controversial issues in the management of acute promyelocytic leukemia (APL) which is the optimal management of relapsed APL following second remission and role of hemato...
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Modern Classification of Acute and Chronic Leukemias: Integrating Biology, Clinicopathologic Features, and Genomics
The modern classification of acute leukemias and myeloid neoplasms has much refinement incorporating clinicopathologic and genomic features with the objective of defining disease entities with information on t...
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Clonal Hematopoiesis and Its Functional Implications in MDS/AML
Clonal hematopoiesis (CH) is now a specifically recognized as a precursor myeloid neoplasm and comprised clonal hematopoiesis of indeterminate potential (CHIP) and clonal cytopenia of undetermined significance...
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Allogeneic Hematopoietic Stem Cell Transplantation for MDS and CMML: When and How?
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains the only curative treatment in both MDS and CMML. In MDS, there is an increasing prevalence of high-risk MDS undergoing HSCT, whereas only...
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Treatment Algorithm for Primary and Secondary Myelofibrosis
The management of primary myelofibrosis (PMF), postpolycythemia vera myelofibrosis (PPV-MF), and postessential thrombocythemia (PET-MF) is driven by their clinicopathologic and genomic characteristics, and the...
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Eosinophilic Disorders and Systemic Mastocytosis
Eosinophilic disorders are a group of rare and highly heterogenous diseases distinguished by increased eosinophil counts and may be associated with end-organ damage. In this chapter, the diagnostic algorithm a...
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In the Pipeline: Emerging Therapy for CML
The development of BCR-ABL1 tyrosine kinase inhibitors (TKI) has revolutionized the treatment of CML. A major limitation of TKI therapy is the relative inability to eradicate quiescence CML leukemic stem cells...
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In the Pipeline: Emerging Therapy for MDS and MDS/MPN
Novel agents in combination with hypomethylating agents are an emerging strategy for clinical trials in involving higher-risk MDS or MDS/MPN and in patients harbouring high-risk mutations such as those involving
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In the Pipeline: Emerging Therapy for Classical Ph-Negative MPNs
Conventional therapy for myeloproliferative neoplasm (MPN) has modest disease-modifying effect. In this chapter, we discuss the emerging novel agents and approaches that may potentially modify the underlying d...
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In the Pipeline: Emerging Therapy for Acute Myeloid Leukaemia
Acute myeloid leukaemia (AML) is an aggressive, heterogenous, and age-related haematological malignancy with dismal prognosis. Conventional therapy for AML consists of frontline induction therapy with cytarabi...
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In the Pipeline—Emerging Therapy for ALL
Despite medical advances in recent decades with improvement in survival rates (Lenk et al., Cancer Metastasis Rev. 2020;39:173–87; Meyer and Hermiston. Cancer Drug Resist. 2019;2: 313–25), decreased treatment ...
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Prognostic Indicators in MDS and CMML
Various prognostic scoring systems have been developed over the last 2 decades aiming to better risk stratify myelodysplastic syndrome (MDS) and chronic myelomonocytic leukemia (CMML). Molecular alterations ar...
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Molecular Landscape and Personalized Prognostic Prediction of MPNs
The past two decades have seen a plethora of studies and observations on driver and non-molecular alterations of prognostic significance in myeloproliferative neoplasm. In this chapter, we describe the molecul...
