12 Result(s)
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Fred Snyder
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Seismic Detection and Quantification of Gas Hydrates using Rock Physics and Inversion
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Biosynthesis of Platelet Activating Factor and Related Acetylated Lipids
Platelet-activating factor (PAF) is synthesized by either de novo or remodeling enzymes (Snyder, 1995a,b). The remodeling of a preexisting membrane phospholipid, 1-alkyl-2-acyl-sn-glycero-3-phosphocholine (alkyla...
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Biosynthesis of Platelet-Activating Factor and Enzyme Inhibitors
Platelet-activating factor (PAF) is known to be synthesized by either a remodeling or de novo pathway. The enzymes responsible have been extensively studied by a number of laboratories. All evidence indicates ...
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Introduction Historical Aspects of Alkyl Lipids and Their Biologically Active Forms (Ether Lipids, Platelet-Activating Factor, and Antihypertensive Renal Lipids)
This introduction reviews highlights of key historical developments that have occurred in research with alkyl ether glycerolipids, platelet-activating factor (PAF), and a group of renal antihypertensive lipids...
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Chromatographic Analyses of Ether-Linked Lipids Involved in PAF Metabolism
A number of chromatographic separations were essential in elucidating the structure of l-alkyl-2-acetyl-sn-glycero-3-phosphocholine [(alkylacetyl-GPC) platelet activating factor (PAF)] (Benveniste et al., 1979; B...
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Enzymatic Pathways for Platelet-Activating Factor, Related Alkyl Glycerolipids, and Their Precursors
The purpose of this chapter is to provide a succinct overview of the enzymatic reaction steps for alkyl glycerolipids and lipid precursors affiliated with the biosynthesis and catabolism of platelet-activating...
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Ether-Linked Glycerolipids and Their Bioactive Species:Enzymes and Metabolic Regulation
The pioneering studies of those scientists who first discovered (1915–1924) and ultimately identified the precise nature of the chemical structure of the alkyl and alk-l-enyl (plasmalogens) linkages in glycero...
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Asymmetric Localization of Alkyldihydroxyacetone-P Synthase and Acyldihydroxyacetone-P Acyltransferase in Microsomal Vesicles
A number of investigations have made it clear that proteases and phospholipases can be used effectively in combination with detergents to determine the topographical distribution of microsomal membrane compone...
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Microsomal Enzymes Involved in the Metabolism of Ether-Linked Glycerolipids and Their Precursors in Mammals
The pathway by which ether-linked glycerolipids are synthesized in animals remained obscure until 1968. Metabolic in vivo studies and structural analysis of alkyl-linked glycerolipids indicated that the alkyl cha...
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Ether-Linked Lipids in Neoplasms of Man and Animals: Methods of Measurement and the Occurrence and Nature of the Alkyl and Alk-1-Enyl Moieties
Naturally occurring glycerolipids containing ether bonds can be classified according to two structural types: alkyl (I), and aik-1-enyl (II).
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Thin-Layer Chromatography Radioassay: A Review
Considerable technological progress has been made in the radioassay of analytical and preparative thin-layer chromatography (TLC) plates since Mangold’s original review of this subject (a chapter in Stahl’s b...
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Zonal Scanning of Thin-Layer Chromatograms
Thin-layer chromatography (TLC) plates have been assayed for radioactivity by autoradiography [1–3], continuous scanning [4–9], area scra** [10–13], and zonal scanning [14]. Direct counting of the thin-layer ad...
