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Chapter
3 Systems Biology Approaches to Understanding and Predicting Fungal Virulence
The identification of fungal virulence factors and novel targets for therapeutic intervention are hindered by the rapid adaptability of pathogenic fungi to their host. One of the major goals of systems biology...
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Chapter and Conference Paper
Zooming in on Yeast Osmoadaptation
Saccharomyces cerevisiae is considered as a model organism for the investigation of cellular and molecular processes and gene regulation. Specifically, the response of S. cerevisiae to increase in osmolarity of ...
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Chapter
Modeling the Dynamics of Stress Activated Protein Kinases (SAPK) in Cellular Stress Response
Experimental research has revealed components and mechanisms of cellular stress sensing, signaling, and adaptation. In addition, mathematical modeling has proven to foster the understanding of basic princi...
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Chapter
The Predictive Power of Molecular Network Modelling
Since the 1960s, the mathematical modelling of intracellular systems, such as metabolic pathways, signal transduction cascades and transport processes, is an ever-increasing field of research. The results of m...
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Chapter
Modelling signalling pathways – a yeast approach
MAP kinase pathways are conserved signalling systems in eukaryotes that control stress responses, cell growth, and proliferation, as well as differentiation. Here, we discuss and compare the feedback control m...
