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    Chapter

    Immune-Mediated Rheumatic Diseases

    Systemic lupus erythematosus (SLE) is the prototypical human, autoimmune disease and is characterized by immune dysregulation, production of autoantibodies, generation of circulating immune complexes, and acti...

    H. Michael Belmont in Challenging Cases in Allergy and Immunology (2009)

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    Chapter

    Rhinitis

    Rhinitis is a common problem encountered daily by most health professionals. Although allergy is the most common cause of rhinitis, the clinician should be aware of the complex differential diagnosis and the v...

    Dennis K. Ledford, Ron Purcell in Challenging Cases in Allergy and Immunology (2009)

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    Chapter

    Allergic Diseases of the Eye

    The eye is a common target of inflammatory responses induced by local and systemic immunological hypersensitivity reactions. Inflammatory ocular conditions resulting from immune responses are highly prominent ...

    Sara Axelrod, Leonard Bielory in Challenging Cases in Allergy and Immunology (2009)

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    Chapter

    Allergic Contact Dermatitis

    Allergic contact dermatitis, an inflammatory skin disease characterized by erythema, edema, vesiculation, and scaling, is a delayed type hypersensitivity reaction following cutaneous exposure to allergenic che...

    Haw-Yueh Thong, Howard I. Maibach in Challenging Cases in Allergy and Immunology (2009)

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    Chapter

    Atopic Dermatitis

    Atopy can be defined as a familial hypersensitivity of skin and mucous membranes against environmental substances, associated with increased immunogloblin E (IgE) production and/or altered unspecific reactivit...

    Satoshi Yoshida in Challenging Cases in Allergy and Immunology (2009)

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    Chapter

    Drug Allergy

    Drug allergy and sensitivity is one of the most challenging presentations that the practicing allergist encounters. Because of the extensively complex nature of these cases and the multiply mediated forms of d...

    Anna Kovalszki, James L. Baldwin in Challenging Cases in Allergy and Immunology (2009)

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    Chapter

    Anaphylaxis

    Anaphylaxis is the most severe presentation of immediate-type hypersensitivity. It occurs rapidly and is often dramatic and unanticipated. Most episodes are not fatal; however, death may occur suddenly through...

    Kris G. McGrath in Challenging Cases in Allergy and Immunology (2009)

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    Chapter

    Occupational Asthma

    Occupational asthma is believed to be responsible for up to 15% of all new cases of asthma in the United States. Evaluation of patients with asthma, therefore, requires a careful and complete work history to i...

    Jonathan A. Bernstein, I. Leonard Bernstein in Challenging Cases in Allergy and Immunology (2009)

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    Chapter

    Mastocytosis

    Mastocytosis is a neoplastic disease involving mast cells (MC) and their CD34+ progenitors and consists of a heterogeneous group of diseases with a clinical spectrum ranging from localized mastocytoma to gener...

    Bettina Wedi, Marianne Frieri in Challenging Cases in Allergy and Immunology (2009)

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    Chapter

    HIV/AIDS and Complications

    In the setting of human immunodeficiency virus (HIV) and acquired immune deficiency syndrome (AIDS), two well-characterized syndromes can present with fevers, rash, headache, and other nonspecific complaints t...

    David Lim, Peter Jensen in Challenging Cases in Allergy and Immunology (2009)

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    Chapter

    Immunodeficiency

    In this chapter, we will describe two cases involving human immune deficiency. One case involves a unique complication while the other case involves an atypical presentation. The first case describes a pregnan...

    Aymeric Louit, Pedro C. Avila in Challenging Cases in Allergy and Immunology (2009)

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    Chapter

    Autoimmune Diseases

    Autoimmune diseases are characterized by autoantibody formation and visceral involvement that is often of an inflammatory nature. Rheumatoid arthritis (RA) is a classic immune complex disease characterized by ...

    Marcy B. Bolster in Challenging Cases in Allergy and Immunology (2009)

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    Chapter

    Chronic Rhinosinusitis

    Rhinosinusitis describes a group of inflammatory conditions of the nasal mucosa and paranasal sinuses that affect 31 million people in the USA each year. When the term chronic rhinosinusitis (CRS) is used, it ...

    Philip Wexler, Helen Hollingsworth in Challenging Cases in Allergy and Immunology (2009)

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    Chapter

    Urticaria and Angioedema

    The different urticaria subtypes represent a common diagnostic and treatment challenge. In acute urticaria that is often induced by an acute infection and/or intake of NSAID such as acetylsalicylic acid, no fu...

    Bettina Wedi, Alexander Kapp in Challenging Cases in Allergy and Immunology (2009)

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    Chapter

    Hypersensitivity Pneumonitis

    Hypersensitivity pneumonitis (HP), also known as extrinsic allergic alveolitis, encompasses a group of pulmonary disorders characterized by immune response to a variety of antigens derived from medications, ch...

    Tracy Prematta, Jennifer Toth, Timothy Craig in Challenging Cases in Allergy and Immunology (2009)

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    Chapter

    Food Allergy

    IgE-mediated food allergies are part of a spectrum of adverse reactions to foods including immune and nonimmune mechanisms. Anaphylaxis is the most serious and life-threatening manifestation of food allergy. A...

    Oscar L. Frick in Challenging Cases in Allergy and Immunology (2009)

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    Chapter

    Eosinophilia and Eosinophilic Disorder

    Eosinophilic disorders are a spectrum of diseases characterized by peripheral eosinophilia and eosinophilic infiltration in various organs. The manifestation of each disease varies by the affected organ. Here,...

    Massoud Mahmoudi in Challenging Cases in Allergy and Immunology (2009)

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    Chapter

    Asthma Conundrums

    Difficult-to-control asthma in adult patients is a conundrum encountered frequently in clinical practice. Recognizing the range of asthma case presentations and conundrums can improve asthma treatment plans an...

    Michael Schivo, Amir A. Zeki in Challenging Cases in Allergy and Immunology (2009)

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    Chapter

    Allergic Bronchopulmonary Aspergillosis

    Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity response to Aspergillus antigens in the lung, which is an uncommon but serious respiratory condition characterized by chronic airway inflammati...

    Satoshi Yoshida in Challenging Cases in Allergy and Immunology (2009)

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    Chapter

    Disorders of Immune Regulation

    Immune system homeostasis is tightly maintained by regulatory mechanisms that allow for the destruction of pathologic microorganisms while preventing pathologic inflammation. Disruption of these regulatory mec...

    Amy L. Marks, Haig Tcheurekdjian in Challenging Cases in Allergy and Immunology (2009)