71 Result(s)
within
Life Sciences
Biotechnology
Chemistry/Food Science, general
Regenerative Medicine/Tissue Engineering
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Chapter
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Lung-on-a-Chip Models of the Lung Parenchyma
Since the publication of the first lung-on-a-chip in 2010, research has made tremendous progress in mimicking the cellular environment of healthy and diseased alveoli. As the first lung-on-a-chip products have...
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Acute and Chronic Wound Management: Assessment, Therapy and Monitoring Strategies
The dynamic nature of the wound healing is a well-studied process. With the rapid evolution of healthcare science, efforts are being made to design newer therapies, along with advancement in the available tech...
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Understanding and Engineering the Pulmonary Vasculature
Blood vessels play essential roles in regulating embryonic organogenesis and adult tissue homeostasis. The inner lining of blood vessels is covered by vascular endothelial cells, which exhibit tissue-specific ...
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Hydrogel-Based Tissue-Mimics for Vascular Regeneration and Tumor Angiogenesis
The vital role of structurally and functionally stable vasculature in engineered tissues is well-established in regenerative medicine. Large-volume, natural, and synthetic tissue constructs require a high degr...
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Clinical Translation of Engineered Pulmonary Vascular Models
Diseases in pulmonary vasculature remain a major cause of morbidity and mortality worldwide. Numerous pre-clinical animal models were developed to understand lung vasculature during diseases and development. H...
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Current and Future Engineering Strategies for ECMO Therapy
Extracorporeal membrane oxygenation (ECMO) is a last resort therapy for patients with respiratory failure where the gas exchange capacity of the lung is compromised. Venous blood is pumped through an oxygenati...
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Mimicking Islet Development with Human Pluripotent Stem Cells
The development of functional beta cells from human pluripotent stem cells (PSCs) offers a promising approach for treating type 1 diabetes (T1D). However, current differentiation protocols often yield heteroge...
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Bioactive Materials for Use in Stem Cell Therapies for the Treatment of Type 1 Diabetes
Diabetes is a major challenge to healthcare providers globally, with significant human and financial costs. Type 1 diabetes is expected to effect more than a million people concurrently, with over 130,000 newl...
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Simple Models of Lung Development
Models are essential to further our understanding of lung development and regeneration and to facilitate identification and testing of potential treatments for lung diseases. A wide variety of rodent and human...
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Correction to: Multipotent Embryonic Lung Progenitors: Foundational Units of In Vitro and In Vivo Lung Organogenesis
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Pancreatic Cell Fate Specification: Insights Into Developmental Mechanisms and Their Application for Lineage Reprogramming
Adult differentiated cells can be forced to switch identities from one cell type to another under the direction of specific transcription factors (TF) in so-called direct lineage reprogramming. The ability to ...
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Immunogenicity of Stem Cell Derived Beta Cells
One of the biggest challenges in beta cell replacement therapy of patients with type 1 diabetes relates to the cause of their disease: islet autoimmunity. The permanent immune suppressive therapy that is the c...
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Regenerative Approaches in the Nervous System
The nervous system is the most unique system of the human body in more than one way. The excitable tissue that forms the nervous system generates and transmits electrical impulses that are responsible for comm...
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Multipotent Embryonic Lung Progenitors: Foundational Units of In Vitro and In Vivo Lung Organogenesis
Transient, tissue-specific, embryonic progenitors are important cell populations in vertebrate development. In the course of respiratory system development, multipotent mesenchymal and epithelial progenitors d...
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The Promises of Pancreatic Progenitor Proliferation and Differentiation
Human pluripotent stem cells (hPSCs) have been proposed as an unlimited source of insulin-secreting pancreatic β cells for diabetes treatment. Many laboratories have demonstrated that hPSCs such as human embry...
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Islet Immunoengineering
From 2000 to 2020, 2170 patients globally received islet allotransplants. Islet transplantation into the hepatic portal vein seeks to replace the insulin-producing β cells that are lost to autoimmunity in type...
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Understanding LncRNAs in Biomaterials Development for Osteointegration
Osseointegration of implants is a sophisticated healing process comprising of blood clot formation, immune response, angiogenesis, and osteogenesis. The features of the blood clots take a crucial role in fulfi...
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Computational, Ex Vivo, and Tissue Engineering Techniques for Modeling Large Airways
The large airways are a critical component of the respiratory tree serving both an immunoprotective role and a physiological role for ventilation. The physiological role of the large airways is to move a large...
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Scaffolds for Encapsulation of Stem Cell-Derived β Cells
Currently, clinical islet transplantation is the most promising minimal invasive therapy to treat the most severe cases of type 1 diabetes, where exogenous insulin administration can no longer be used to contr...
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Genetic Safety Switches for Pluripotent Stem Cell-Derived Therapies for Diabetes
As human pluripotent stem cell (hPSC)-derived therapies move towards clinical application, ensuring the safety of transplanted cell populations remains a critical concern. Because undifferentiated hPSC are hig...
