18 Result(s)
within
Life Sciences
Biomaterials
Biotechnology
Cell Biology
Chemistry/Food Science, general
Regenerative Medicine/Tissue Engineering
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Chapter
Lung-on-a-Chip Models of the Lung Parenchyma
Since the publication of the first lung-on-a-chip in 2010, research has made tremendous progress in mimicking the cellular environment of healthy and diseased alveoli. As the first lung-on-a-chip products have...
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Understanding and Engineering the Pulmonary Vasculature
Blood vessels play essential roles in regulating embryonic organogenesis and adult tissue homeostasis. The inner lining of blood vessels is covered by vascular endothelial cells, which exhibit tissue-specific ...
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Clinical Translation of Engineered Pulmonary Vascular Models
Diseases in pulmonary vasculature remain a major cause of morbidity and mortality worldwide. Numerous pre-clinical animal models were developed to understand lung vasculature during diseases and development. H...
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Current and Future Engineering Strategies for ECMO Therapy
Extracorporeal membrane oxygenation (ECMO) is a last resort therapy for patients with respiratory failure where the gas exchange capacity of the lung is compromised. Venous blood is pumped through an oxygenati...
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Simple Models of Lung Development
Models are essential to further our understanding of lung development and regeneration and to facilitate identification and testing of potential treatments for lung diseases. A wide variety of rodent and human...
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Correction to: Multipotent Embryonic Lung Progenitors: Foundational Units of In Vitro and In Vivo Lung Organogenesis
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Multipotent Embryonic Lung Progenitors: Foundational Units of In Vitro and In Vivo Lung Organogenesis
Transient, tissue-specific, embryonic progenitors are important cell populations in vertebrate development. In the course of respiratory system development, multipotent mesenchymal and epithelial progenitors d...
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Computational, Ex Vivo, and Tissue Engineering Techniques for Modeling Large Airways
The large airways are a critical component of the respiratory tree serving both an immunoprotective role and a physiological role for ventilation. The physiological role of the large airways is to move a large...
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Engineering and Modeling the Lung Mesenchyme
The structure of the mammalian lung controls the flow of air through the airways and into the distal alveolar region where gas exchange occurs. Specialized cells in the lung mesenchyme produce the extracellula...
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Assessment of Collagen in Translational Models of Lung Research
The extracellular matrix (ECM) plays an important role in lung health and disease. Collagen is the main component of the lung ECM, widely used for the establishment of in vitro and organotypic models of lung d...
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An Overview of Organ-on-a-Chip Models for Recapitulating Human Pulmonary Vascular Diseases
Traditionally, animal models have been used for recapitulating human physiology and for studying the pathological basis of many diseases affecting humankind. Indeed, over the centuries, animal models helped ad...
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Extracorporeal Membrane Oxygenation: Set-up, Indications, and Complications
Extracorporeal membrane oxygenation (ECMO) occupies an increasingly important position in the clinic for the management of cardiac and/or pulmonary failure. As a rescue therapy, ECMO can support patients follo...
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An Introduction to Engineering and Modeling the Lung
Over the last decade, the field of lung biology has evolved considerably due to many advancements, including the advent of single-cell RNA (scRNA) sequencing, induced pluripotent stem cell (iPSC) reprogramming...
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Correction to: Lung Development in a Dish: Models to Interrogate the Cellular Niche and the Role of Mechanical Forces in Development
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Lung Development in a Dish: Models to Interrogate the Cellular Niche and the Role of Mechanical Forces in Development
Over the past decade, emphasis has been placed on recapitulating in vitro the architecture and multicellular interactions found in organs in vivo [1, 2]. Whereas traditional reductionist approaches to in vitro...
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Basic Science Perspective on Engineering and Modeling the Large Airways
The airway epithelium provides a physical and biochemical barrier playing a key role in protecting the lung from infiltration of pathogens and irritants and is, therefore, crucial in maintaining tissue homeost...
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Engineering Large Airways
A key issue facing trachea replacement attempts has been the discrepancy of the mechanical properties between the native tracheal tissue and that of the replacement construct; this difference is often one of t...
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Engineering Dynamic 3D Models of Lung
The lung parenchyma—consisting of gas-filled alveoli, vasculature, and connective tissue—is the site for gas exchange in the lung and plays a critical role in a number of chronic lung diseases. In vitro models...
