50 Result(s)
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Chapter
Inherited Immune Deficiency
The immune system provides protection from infectious agents, using two major lymphocyte subsets, known as T cells and B cells. The immune system can respond specifically to millions of different stimuli (epit...
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Chapter
Patterns of TP53 Mutations in Human Cancer: Interplay Between Mutagenesis, DNA Repair and Selection
Somatic mutations are the cornerstone of cancer (Hanahan et al. 2000). The development of cancer involves the contributions of many heritable genetic events as well as of a large number of epigenetic changes, ...
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Chapter
Small-molecule Hsp90 Inhibitors: Applications in Cancer and Neurodegenerative diseases
Hsp90 is a pleiotropic cytoplasmic chaperone that regulates an ever-growing list of client proteins. Hsp90 clients include many, but not all, kinases, steroid receptors and a number of transcription factors. M...
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Chapter
Animal Models of Stress Urinary Incontinence
Stress urinary incontinence (SUI) is a common health problem significantly affecting the quality of life of women worldwide. Animal models that simulate SUI enable the assessment of the mechanism of risk facto...
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Chapter
Erratum
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Chapter
Role of Reactive Oxygen Species Formation from Oxidized Low Density Lipoprotein in Bone Marrow Stem Cells
Reactive oxygen species (ROS) are a group of small molecules that regulate tissue redox status and oxidative stress. Redox regulation is an important determinant for cell development, activities, and function....
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Chapter
Protein Sequence–Structure–Function–Network Links Discovered with the ANNOTATOR Software Suite: Application to ELYS/Mel-28
While very little genomic sequence is interpretable in terms of biological mechanism directly, the chances are much better for protein-coding genes that can be translated into protein sequences. This review co...
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Chapter
STIM-TRP Pathways
Receptor-evoked Ca2+ influx is a central component of the Ca2+ signal. A ubiquitous form of Ca2+ influx is activated by depletion of endoplasmic Ca2+ stores, the SOC channels. The two established Ca2+ influx chan...
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Chapter
The Clinical Significance of Mutations in Colorectal Cancer
Genetic mutations are emerging as critical factors in treatment decisions for colorectal cancer. In this chapter, we review the clinical data for predictive and prognostic genetic markers. While a prognostic r...
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Chapter
DNA Repair Mechanisms in Breast Cancer Stem Cells
Breast cancer stem cells (BCSC) are a small subset in heterogeneous breast cancer cell populations and are responsible for breast cancer initiation. BCSC have stem cell properties. The maintenance and propagan...
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Chapter
Autophagy and Cancer Drug Discovery
Autophagy is a highly conserved lysosomal degradation pathway that is important for maintaining cellular homeostasis by degrading bulk cytoplasm and superfluous or damaged organelles. Autophagy plays a dual ro...
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Chapter
Epigenetic Mechanisms of Colon Cancer Prevention: What Can Nutrition Do?
Colon cancer is the fourth most common cause of death from cancer worldwide. Colon cancer occurs as a consequence of the accumulation of abnormal DNA methylation and the disruption of the histone code. The pre...
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Chapter
Erratum to: ABC Transporter Modulatory Drugs from Marine Sources: A New Approach to Overcome Drug Resistance in Cancer
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Chapter
Host Factors and Risk of Breast Cancer Recurrence: Genetic, Epigenetic and Biologic Factors and Breast Cancer Outcomes
Among women with breast cancer, there is wide variability in outcomes, both in treatment-related toxicities and disease-free survival (DFS). Primary predictors of DFS are those related to the extent of the dis...
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Chapter
Modifiable Lifestyle Factors and Breast Cancer Outcomes: Current Controversies and Research Recommendations
Lifestyle factors, particularly obesity, have been associated with poor breast cancer outcomes in a large number of observational studies. Despite a growing body of research, controversy exists regarding obesi...
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Chapter
ABC Transporter Modulatory Drugs from Marine Sources: A New Approach to Overcome Drug Resistance in Cancer
Fighting this unconquerable mammoth of a disease that is cancer has been increasingly difficult from its discovery over a century ago. A multitude of agents have been identified in the past to conquer the batt...
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Chapter
Therapeutic Implications of Cancer Stem Cell: Challenges and Opportunities in Translational Studies
Cancer stem cells (CSCs) are rare in cancer population, but they can reconstruct the whole bulk of tumor if most of the cancer cells are killed by radiotherapy or chemotherapy. However, the mechanism of CSCs’ ...
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Chapter
Comorbidities and Their Management: Potential Impact on Breast Cancer Outcomes
Pre-existing comorbidities negatively impacts overall breast cancer prognosis, increasing both breast cancer specific deaths as well as death from competing causes. Improvements in breast cancer survival in re...
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Chapter
Anaplastic Lymphoma Kinase (ALK) Signaling in Lung Cancer
Chromosomal rearrangement in the anaplastic lymphoma kinase (ALK) gene was identified as an oncogenic driver in non-small cell lung cancer (NSCLC) in 2007. A multi-targeted ALK/ROS1/MET inhibitor, crizotinib, tar...
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Chapter and Conference Paper
Efficient Protocol for the Identification of Hypoxic Cell Radiosensitisers
An evolution in radiotherapy practice is leading to greater use of stereotactic body radiotherapy (SBRT), raising the prospect of increased hypoxic cell radioresistance. New clinical interest in nitroimidazole...
