123 Result(s)
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Chapter and Conference Paper
Response to an Active Vitamin D3 Metabolite of Transplantable Human Myeloid Leukemic Cell Lines in Adult Nude Mice
Tumorigenicity of human myeloid leukemic cell lines KG-1, U937, HL-60 and K562 was studied in adult cyclophosphamide-primed nude mice (CPNM). All inocula except KG-1 consistently grew nonmet-astatic subcutaneo...
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Chapter and Conference Paper
Expression of Cellular Oncogenes in Primary Cells from Human Leukemias
Alterations of cellular oncogene expression have been reported in numerous neoplasias, particularly of the hematopoietic system. However, a cause-effect relationship between cellular oncogene abnormalities and...
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Chapter and Conference Paper
Use of All-trans Retinoic Acid in the Treatment of Acute Promyelocyte Leukemia
Acute promyelocytic leukemia (APL) is considered to be a distinct entity among the acute myeloid leukemias (AMLs). Hemorrhagic diathesis often occurs and results in a rapid fatal outcome. The bleeding episodes...
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Chapter
Androgen Regulation of HBGF-I (aFGF) mRNA and Characferization of the Androgen-Receptor mRNA in the Human Prostate Carcinoma Cell Line-LNCaP/A-Dep
A low serum media was developed for growing LNCaP/A-dep cells. It was demonstrated that testosterone at 10-9M can stimulate growth 5-fold. The anti-androgens, cyproterone acetate and hydroxyflutamide, also stimul...
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Chapter and Conference Paper
Androgen Regulation of Growth Factor and Early Growth Repsonse Gene Expression in Hamster DDT1-MF2 and Human Prostate LNCAP Cells
The Syrian hamster DDT-1 cell line was originally derived from an estrogen/androgen-induced ductus deferens tumor and has served as a model for analyzing androgen-induced growth (1). Likewise a human prostate ...
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Chapter
Molecular Design and Synthesis of B-10 Carriers for Neutron Capture Therapy
We have developed several new synthetic methods for B-10 containing bio-related molecules.(1)The palladium-catalyzed coupling reaction of halogenated nucleoside derivatives with the aryltin compound having a b...
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Chapter and Conference Paper
The Hemolymph Coagulation System of Shrimps
The effects of different anticoagulants on the shrimp coagulation systems were studied. Metal ion chelators, Zn2+, Hg2+, serine protease inhibitors and some transglutaminase-inhibitors were found to inhibit the c...
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Chapter and Conference Paper
Prevalence of Hepatitis C Virus Infection in Nan**g, Southern China
We examined the prevalence of hepatitis C virus (HCV) infection among people without apparent liver disease and patients with various liver diseases in Nan**g, southern China. Also, we determined the sequence...
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Chapter
Studies on Pretreatment of Human Fetal Islet In Vitro and Clinical Islet Transplantation in China
We have been undertaking the studies on experimental islet transplantation since 1978 and clinical islet transplantation with short-term cultured human fetal islet tissue in patients with insulin-dependent (ty...
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Chapter and Conference Paper
Analysis of cerebrospinal fluid of patients with parkinsonism by proton nuclear magnetic resonance spectroscopy
High-resolution proton magnetic resonance spectroscopy was used to study the concentrations of metabolites in the cerebrospinal fluid (CSF) of patients with parkinsonism. The results indicated that the glucose...
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Chapter
Synthesis of 5-S-Alkylcarboranyl-2′-Deoxyuridines
Since glioma cells are more mitotically active than normal brain cells, they have an increased demand for nucleic acids to synthesize DNA. Several boronated nucleosides have been synthesized to take advantage ...
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Chapter and Conference Paper
Detection and Diagnosis of Small Hepatocellular Carcinoma: Techniques of Computed Tomography and Imaging Modalities
Hepatocellular carcinoma (HCC) is the predominant type of primary cancer accounting for over 90% of cancers in China [1]. The incidence of HCC varies greatly from country to country and is particularly prevale...
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Chapter
The Role of Endothelium and of Extracellular and Intracellular Acidosis for Hypercapnia Induced Inhibition of Tension of Isolated Rat Cerebral Arteries
The importance of changes in extracellular and intracellular pH (pH0 and pHi) for hypercapnic vasodilation was evaluated in vitro. Segments of the middle cerebral artery of the rat were mounted in a myograph for ...
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Chapter
Synthesis and Biochemical Evaluation of 5-Tethered Boron-Containing Pyrimidine Nucleosides for BNCT
In order for BNCT to be successful, a major need is the development of boron compounds, which penetrate the blood-brain barrier (BBB), target tumor cells selectively, and maintain a relatively high concentrati...
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Chapter
Murine AIDS Cured by Low Dosage Total Body Irradiation
Animal models are useful for establishing the potential efficacy of various treatment protocols. A murine hematological disease induced by Friend leukemia virus (FLV, retrovirus) is accompanied by a severe imm...
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Chapter
The Therapeutic Effect of Naturin-2 on Lewis Lung Carcinoma and Murine-AIDS
The immune system plays a major role in immuno-surveillance, and its impairment has been linked to cancer and immuno-deficiency disorders including AIDS. (1–3) The biological response modifier (BRM) is a term ...
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Chapter
Dynamic Cerebral Autoregulation at High Altitude
Cerebral autoregulation is a dynamic process that is frequency dependent. In other words, the ability of local vascular control mechanisms to buffer changes in arterial pressure and keep cerebral blood flow (C...
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Chapter
Dietary and Nutritional Modulation of Tumor Angiogenesis
Tumor angiogenesis is intimately linked to the dynamic interactions between the nutrient status of the host and the tumor. It is well recognized that a growing tumor requires a vascular supply to provide oxyge...
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Chapter and Conference Paper
Surgical Results of Photorefractive Keratectomy Using Different Operative Modes
Purpose: To compare the predictability, efficacy, and safety of photorefractive keratectomy (PRK) by using differen excimer laser treatment modes.
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Chapter
Evaluation of Carboranyl 2′-Deoxyuridine Derivatives as Substrates for Human Thymidine Kinases 1 and 2
Cellular nucleoside kinases play a pivotal role in the use of nucleosides for cancer and antiviral therapy.1 For BNCT, the cytosolic thymidine kinase (TK1) may be a particularly important target enzyme. TK1 activ...
