92 Result(s)
within
Chapter
**ao Rong
Biomedicine
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Chapter
Monoclonal Antibodies: From Structure to Therapeutic Application
The exciting field of therapeutic monoclonal antibodies (mAbs) had its origins when Köhler and Milstein presented their murine hybridoma technology in 1975 (Kohler, Milstein. Nature. 256(5517):495–497, 1975). ...
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Chapter
Recent Advances of Iron Oxide Nanoparticles-Based Nanomedicine for Prostate Cancer (Review)
Prostate cancer (PC) is one of the commonly diagnosed cancers among men in the world. Clinical outcomes are excellent for patients with localized disease; however, patients with metastatic castration-resistant...
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Chapter and Conference Paper
Retinal Metabolic Profile on IMPG2 Deficiency Mice with Subretinal Lesions
The interphotoreceptor matrix (IPM) is the extracellular matrix between the photoreceptors and the retinal pigment epithelium (RPE). The IPM has two proteoglycans: the IPM proteoglycans 1 and 2 (IMPG1 and IMPG...
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Chapter
Inflammation and Pain
Inflammation is the body’s natural response to injury or the infiltration of a foreign substance. The process is defined by five cardinal signs: redness, heat, swelling, loss of function, and pain. Because of ...
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Chapter
Inflammatory Mediators, Nociceptors, and Their Interactions in Pain
Inflammation produces pro-inflammatory mediators for the induction of pain. These mediators include inflammatory cytokines and chemokines, lipids, and microRNAs. These inflammatory mediators bind respective re...
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Chapter
Sex Differences in Pain with Emphasis on Neuroimmune Interactions
To date, the mechanisms underlying how neuroimmune interactions contribute to sex dimorphism of chronic pain remain elusive. Although women suffer from chronic pain at greater rates than men, the current mecha...
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Chapter
Mechanisms-Based Pain Therapies
Chronic pain is a prevalent disease with high impact on public health and individual’s quality of life. Understanding the complex mechanisms and causes of pain is crucial for precise diagnosis, adequate manage...
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Chapter
AOP-Based Machine Learning for Toxicity Prediction
On a daily basis, people will be exposed to various compounds, many of which potentially endanger human life and health. Therefore, there is a driving imperative to evaluate the toxic effects of these compound...
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Chapter
Animal Models of Pain and Anti-inflammatory Treatments
Animal models are critical to the field of pain research, both for the study of mechanisms and the testing of novel therapeutics. Unfortunately, many findings that appear promising in animals fail to translate...
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Chapter
Immune and Glial Cells in Pain and Their Interactions with Nociceptive Neurons
While pain is sensed and conducted by neurons, including primary sensory neurons (nociceptors) and spinal cord pain transmission neurons, mounting evidence suggests that non-neuronal cells such as immune cells...
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Chapter
Neuroimmune Interactions in Acute and Chronic Itch
Itch is a sensory experience of the skin that is familiar to all humans. Recent studies have established that the immune system and central and peripheral nervous systems engage in extensive interactions terme...
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Chapter
Immunotherapy and Pain
Immunotherapy was initially developed as a method to treat cancer through the use of the host’s immune system. Now, immunotherapy is used as a treatment for a wide variety of diseases. The connection between t...
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Chapter
Exercise and Diet in the Control of Inflammation and Pain
Lifestyle choices, such as exercise and diet, can play significant roles in mediating inflammation and consequently, pain. Functional medicine is an emerging medical specialty that focuses on lifestyle influen...
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Chapter
Ebola Virus Entry Inhibitors
Ebola virus (EBOV) is one of the most deadliest agents already known, causing periodic epidemic of a severe hemorrhagic fever disease in Africa. Although two monoclonal antibody (mAb) drugs have recently recei...
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Chapter
Correction to: Notch Signaling and Human Papillomavirus–Associated Oral Tumorigenesis
Unfortunately the book was published without correcting a typo in the author name in chapter 8. The author name has been corrected now to read as follows:
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Chapter
Gene Manipulation Protocols in Autophagy
Macroautophagy (referred to as autophagy hereafter) is a highly conserved catabolic process in eukaryotic cells. Autophagy is essential for cellular homeostasis through elimination and recycling of large cytop...
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Chapter
China-Zanzibar Cooperation Project of Schistosomiasis Control: Study Design
Schistosomiasis is a public health problem mostly in Africa. In 2014, World Health Organization (WHO) signed a tripartite memorandum of understanding (MOU) with China and Tanzania-Zanzibar paving the way for p...
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Chapter
Toxicological Effects of BPDE on Dysfunctions of Female Trophoblast Cells
Polycyclic aromatic hydrocarbons (PAHs) are widely spread persistent environmental toxicants. Its typical representative benzo[a]pyrene (BaP) is a human carcinogen. BaP can pass through the placental barrier a...
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Chapter
Bulinus Snails Control by China-made Niclosamide in Zanzibar: Experiences and Lessons
Schistosomiasis haematobium is one of the most important, but often neglected, tropical diseases transmitted by snails of Bulinus in Zanzibar. Snail control by mollusciciding is the cornerstone in preventing the ...
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Chapter
Intracellular Signaling Cascades in Bipolar Disorder
Bipolar spectrum disorders carry a significant public health burden. Disproportionately high rates of suicide, incarceration, and comorbid medical conditions necessitate an extraordinary focus on understanding...
