31 Result(s)
within
Biomedicine
Biochemistry, general
Cell Biology
**-** Wang
Chapter
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Chapter and Conference Paper
Field trial of an inactivated vaccine against hemorrhagic fever with renal syndrome in humans
Hantaan virus was serially passaged in the brains of suckling rats. Vaccine inactivated with formalin was prepared from the suckling rat brains and the antigenic potency of the vaccine was determined by enzyme...
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New Methodologies in Heparin Structure Analysis and the Generation of LMW Heparins
This chapter examines the methods used to prepare heparin, low molecular weight (LMW) heparins, and immobilized heparins. These heparins and heparin derivatives are polydisperse heterogeneous mixtures that req...
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Microsomal Amidases and Carboxylesterases
Deacylation is an important biological reaction which affects the efficacy and toxicity of chemotherapeutic amides and the carcinogenicity of aryl and heterocyclic amides. It is catalyzed by amidases, a group ...
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Apoptosis, Cancer, and Cancer Therapy
Apoptosis is a complex process involving a large array of genes and mutation of any of these genes may lead to malignancy formation. Tumor cells may actively evade the immune surveillance by actively inducing ...
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Targeting the Poly (ADP-Ribose) Glycohydrolase (PARG) Gene in Mammals
Poly(ADP-ribosyl)ation is a post-translational modification of proteins. Upon DNA damage, poly(ADP-ribose) polymerase-1 catalyzes the transfer of ADP-ribose moieties from NAD+ onto acceptor proteins to form long ...
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Engineering the Secretory Pathway in Mammalian Cells
There has been rapid growth in the commercial market for biopharmaceuticals, most of which are produced in mammalian cells as secreted recombinant products. Thus, cellular engineering strategies, involving mod...
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Chemical, Biochemical, and Biological Behaviors of Vanadate and Its Oligomers
Vanadate is widely used as an inhibitor of protein tyrosine phosphatases (PTPase) and is routinely applied in cell lysis buffers or immunoprecipitations of phosphotyrosyl proteins. Additionally, vanadate has b...
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Biogenic Inorganic Polysilicates (Biosilica): Formation and Biomedical Applications
The siliceous sponges, the demosponges and hexactinellid glass sponges, are unique in their ability to form biosilica structures with complex architectures through an enzyme-catalyzed mechanism. The biosilica ...
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Inorganic Polyphosphates: Biologically Active Biopolymers for Biomedical Applications
Inorganic polyphosphate (polyP) is a widely occurring but only rarely investigated biopolymer which exists in both prokaryotic and eukaryotic organisms. Only in the last few years, this polymer has been identi...
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Inorganic Polymers: Morphogenic Inorganic Biopolymers for Rapid Prototy** Chain
In recent years, considerable progress has been achieved towards the development of customized scaffold materials, in particular for bone tissue engineering and repair, by the introduction of rapid prototy**...
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Nuclear Functions and Trafficking of Receptor Tyrosine Kinases
Accumulating evidence suggests that alteration of subcellular protein localization and compartmentalization results in various types of cancer. Since the receptor tyrosine kinases (RTKs) are highly expressed ...
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PDCD4
PDCD4 is a novel tumor suppressor. Its expression is frequently downregulated in many types of cancers, and it has been demonstrated to inhibit tumor promotion and progression. The biochemical function of PDCD...
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MicroRNAs in Solid Tumors
MicroRNAs (miRNAs) are small noncoding RNAs (17–25 nt) that modulate the expression of genes by negatively regulating translation and stability of messenger RNAs (mRNAs). miRNAs have emerged as critical player...
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Tfh Cell Differentiation and Their Function in Promoting B-Cell Responses
Follicular helper T cells (Tfh) are a newly defined helper T-cell subset that is specialized in facilitating B-cell responses. These cells have a unique tissue localization pattern and a distinct transcription...
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Target-Recognition Mechanism and Specificity of RNA Activation
Small activating RNA (saRNA)-mediated gene activation has opened a new avenue for upregulating the expression of target genes by promoting endogenous transcription, a phenomenon known as RNA activation (RNAa)....
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Promoter-Targeted Small Activating RNAs Alter Nucleosome Positioning
Epigenetic modification of target promoters has been identified as a mechanism underlying RNA activation (RNAa) induced by promoter-targeting small activating RNAs (saRNAs), but it is unclear how the chromosom...
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Circular RNAs in Metabolic Diseases
Metabolic diseases include diabetes mellitus (DM), obesity, metabolic syndrome, and non-alcoholic fatty liver disease (NAFLD). Circular RNA is a new type of RNA that is different from traditional linear RNA an...
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Circular RNAs as Biomarkers for Cancer
As a type of novel noncoding RNAs, circular RNAs (circRNAs) have attracted great interest due to its different characteristics from linear RNAs. They are abundantly and stably present in the transcriptome of e...
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Circular RNA in Liver: Health and Diseases
Circular RNA (circRNA) is an important class of noncoding RNA characterized by covalently closed continuous loop structures. In recent years, the various functions of circRNAs have been continuously documented...
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Circular RNAs as Novel Biomarkers for Cardiovascular Diseases
Cardiovascular diseases are among the most serious diseases, which are a leading cause of death across the world. Early diagnosis and prognosis prediction are keys for treatment and reduction of death rates. C...
