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Novel genomic variants related to visceral adiposity index (VAI) and body adiposity index (BAI) in Indian sib-pairs
BackgroundObesity is among the leading public health threats globally. Over the last few years, visceral adiposity index (VAI), and body adiposity...
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Genetic therapies for cardiomyopathy: survey of attitudes of the patient community for the CureHeart project
Cardiomyopathies are a group of inherited heart muscle disorders. Expressivity is variable and while sometimes mild, complications can result in...
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Atorvastatin exerts a preventive effect against steroid-induced necrosis of the femoral head by modulating Wnt5a release
Steroid-induced osteonecrosis of the femoral head (SONFH) is a prevalent form of osteonecrosis in young individuals. More efficacious clinical...
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Quantifying impairment and disease severity using AI models trained on healthy subjects
Automatic assessment of impairment and disease severity is a key challenge in data-driven medicine. We propose a framework to address this challenge,...
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An investigation of inequalities in exposure to PM2.5 air pollution across small areas in Ireland
The link between exposure to air pollution and adverse effects on human health is well documented. Yet, in a European context, research on the...
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Accuracy of dental implant placement using different dynamic navigation and robotic systems: an in vitro study
Computer-aided implant surgery has undergone continuous development in recent years. In this study, active and passive systems of dynamic navigation...
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Aqp4a and Trpv4 mediate regulatory cell volume increase for swimming maintenance of marine fish spermatozoa
Volume regulation is essential for cell homeostasis and physiological function. Amongst the sensory molecules that have been associated with volume...
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Effect of in-line filtration in newborns: study protocol of the Intravenous Neonatal Central Access Safety (INCAS) randomized controlled trial
BackgroundParticulate contamination due to infusion therapy (administration of parenteral nutrition and medications) carries a potential health risk...
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The effectiveness and safety of acupoint herbal patching for allergic rhinitis: protocol for a systematic review and meta-analysis
BackgroundAllergic rhinitis (AR) is a common inflammatory disease of the nasal mucosa that is characterized by symptoms such as sneezing, nasal...
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Endogenous LXR signaling controls pulmonary surfactant homeostasis and prevents lung inflammation
Lung type 2 pneumocytes (T2Ps) and alveolar macrophages (AMs) play crucial roles in the synthesis, recycling and catabolism of surfactant material, a...
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In vivo photocontrol of orexin receptors with a nanomolar light-regulated analogue of orexin-B
Orexinergic neurons are critically involved in regulating arousal, wakefulness, and appetite. Their dysfunction has been associated with slee**...
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Human cytomegalovirus infection impairs neural differentiation via repressing sterol regulatory element binding protein 2-mediated cholesterol biosynthesis
Congenital human cytomegalovirus (HCMV) infection is a major cause of abnormalities and disorders in the central nervous system (CNS) and/or the...
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Development and validation of a clinical nomogram to predict prostatic inflammation in men with lower urinary tract symptoms
BackgroundProstatic inflammation is an important etiological component of benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS)....
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A transversal cross-sectional study of factors related to HPV vaccination status and cancer screening participation among French women aged 25–40
BackgroundIn 2020, uterine cervical cancer (UCC) was the 12th most common cancer among women in France and the 4th worldwide. French health...
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Deep learning for multi-type infectious keratitis diagnosis: A nationwide, cross-sectional, multicenter study
The main cause of corneal blindness worldwide is keratitis, especially the infectious form caused by bacteria, fungi, viruses, and Acanthamoeba. The...
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High-intensity Focused Ultrasound-A New Choice to Conduct Pulmonary Artery Denervation
This research aimed to explore whether high-intensity focused ultrasound (HIFU) could conduct pulmonary artery denervation (PADN). HIFU was performed...
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Plasma Biomarker Screening Based on Proteomic Signature of Patients with Resistant Hypertension
Resistant hypertension (RH) poses a significant health challenge, yet its underlying pathogenesis remains unclear. This study employs untargeted...
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Epidemiological studies of Isoparorchis hypselobagri (Digenea: Trematoda) infecting freshwater catfish Wallago attu in the Aligarh region of Uttar Pradesh
Fisheries and aquaculture are crucial for ensuring food security and are significant sources of income and social advancement in develo** nations....
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Homoharringtonine may help improve the outcomes of venetoclax and azacitidine in AML1-ETO positive acute myeloid leukemia
PurposeT(8;21)(q22;q22.1)/AML1-ETO positive acute myeloid leukemia (AE-AML) is sensitive to conventional chemotherapy with a favorable prognosis....
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Unconventional posttranslational modification in innate immunity
Pattern recognition receptors (PRRs) play a crucial role in innate immunity, and a complex network tightly controls their signaling cascades to...
