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Development and validation of a clinical nomogram to predict prostatic inflammation in men with lower urinary tract symptoms
BackgroundProstatic inflammation is an important etiological component of benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS)....
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A review of plastic waste nanocomposites: assessment of features and applications
Hundreds of millions of metric tons of plastic waste are generated globally every year. Processing waste into secondary raw material is preferred...
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Aqp4a and Trpv4 mediate regulatory cell volume increase for swimming maintenance of marine fish spermatozoa
Volume regulation is essential for cell homeostasis and physiological function. Amongst the sensory molecules that have been associated with volume...
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Quantifying impairment and disease severity using AI models trained on healthy subjects
Automatic assessment of impairment and disease severity is a key challenge in data-driven medicine. We propose a framework to address this challenge,...
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The ethics of artificial intelligence systems in healthcare and medicine: from a local to a global perspective, and back
Artificial intelligence systems (ai-systems) (e.g. machine learning, generative artificial intelligence), in healthcare and medicine, have been...
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Endogenous LXR signaling controls pulmonary surfactant homeostasis and prevents lung inflammation
Lung type 2 pneumocytes (T2Ps) and alveolar macrophages (AMs) play crucial roles in the synthesis, recycling and catabolism of surfactant material, a...
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In vivo photocontrol of orexin receptors with a nanomolar light-regulated analogue of orexin-B
Orexinergic neurons are critically involved in regulating arousal, wakefulness, and appetite. Their dysfunction has been associated with slee**...
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Human cytomegalovirus infection impairs neural differentiation via repressing sterol regulatory element binding protein 2-mediated cholesterol biosynthesis
Congenital human cytomegalovirus (HCMV) infection is a major cause of abnormalities and disorders in the central nervous system (CNS) and/or the...
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Dual polarity open circuit voltage in triboelectric nanogenerators originated from two states series impedance
Experimental and simulation studies demonstrated that the initial voltage setting significantly influences the open-circuit voltage ( V OC ) in...
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Unconventional posttranslational modification in innate immunity
Pattern recognition receptors (PRRs) play a crucial role in innate immunity, and a complex network tightly controls their signaling cascades to...
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Preliminary field validity of ActiGraph-based energy expenditure estimation in wheelchair users with spinal cord injury
Study designCross-sectional validation study.
ObjectivesTo develop a raw acceleration signal-based random forest (RF) model for predicting total...
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Proteomic analysis of lung responses to SARS-CoV-2 infection in aged non-human primates: clinical and research relevance
With devastating health and socioeconomic impact worldwide, much work is left to understand the Coronavirus Disease 2019 (COVID-19), with emphasis in...
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Homoharringtonine may help improve the outcomes of venetoclax and azacitidine in AML1-ETO positive acute myeloid leukemia
PurposeT(8;21)(q22;q22.1)/AML1-ETO positive acute myeloid leukemia (AE-AML) is sensitive to conventional chemotherapy with a favorable prognosis....
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UBQLN4 promotes the proliferation and invasion of non-small cell lung cancer cell by regulating PI3K/AKT pathway
BackgroundUbiquilin-4 (UBQLN4), a member of the ubiquilin family, has received limited attention in cancer research to date. Here, we investigated...
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Molecular dynamics study on the thermal properties of DGEBA/DETA/Ag/SWCNT-Ag composite materials
ContextTraditional conductive adhesives based on epoxy resin system often encounter problems such as high brittleness and low heat resistance....
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Fine map** of candidate effector genes for heart rate
An elevated resting heart rate (RHR) is associated with increased cardiovascular mortality. Genome-wide association studies (GWAS) have...
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FOXM1 c.1205 C > A mutation is associated with unilateral Moyamoya disease and inhibits angiogenesis in human brain endothelial cells
Unilateral moyamoya disease (MMD) represents a distinct subtype characterised by occlusive changes in the circle of Willis and abnormal vascular...
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Angelica sinensis polysaccharides promote extramedullary stress erythropoiesis via ameliorating splenic glycolysis and EPO/STAT5 signaling-regulated macrophages
Conventional treatments exhibit various side effects on chronic stress anemia. Extramedullary stress erythropoiesis is a compensatory mechanism,...
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Lhx4 surpasses its paralog Lhx3 in promoting the differentiation of spinal V2a interneurons
Paralog factors are considered to ensure the robustness of biological processes by providing redundant activity in cells where they are co-expressed....
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Materials advancements for the safety and patency of implantable cardiovascular devices
Implantable cardiovascular devices have revolutionized the management of cardiovascular diseases, significantly enhancing patients’ quality of life....
