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Biomarkers In Prediction of Acute Mesenteric Ischaemia: a prospective multicentre study (BIPAMI study): a study protocol
BackgroundAcute mesenteric ischaemia (AMI) is a life-threatening disease where early diagnosis is critical to avoid morbidity and mortality from...
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Treatment Strategies for Filamentous Fungi Keratitis
IntroductionThis research aims to describe clinical findings, epidemiology and treatment outcomes in patients with filamentous fungi keratitis of a...
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Semaphorin 3C (Sema3C) reshapes stromal microenvironment to promote hepatocellular carcinoma progression
More than 90% of hepatocellular carcinoma (HCC) cases develop in the presence of fibrosis or cirrhosis, making the tumor microenvironment (TME) of...
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Prolonged water-only fasting in the management of low-grade follicular lymphoma: a case series
BackgroundFollicular lymphoma typically follows an indolent and relapsing course often requiring several treatment cycles to achieve remission. Some...
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Insomnia During Late Life: Potential Pathways Toward Suicide Risk
Purpose of ReviewAs the global population continues to age, the identification of drivers of suicide risk in older adults is of increasing...
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In silico exploration of anti-prostate cancer compounds from differential expressed genes
Prostate cancer (PCa) is a complex and biologically diverse disease with no curative treatment options at present. This study aims to utilize...
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Drug-related emergency department visits: external validation of an assessment tool in a general emergency department population
BackgroundThe process of identifying drug-related hospitalisations is subjective and time-consuming. Assessment tool for identifying hospital...
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Vertebral bone quality score was associated with paraspinal muscles fat infiltration, but not modic classification in patients with chronic low back pain: a prospective cross-sectional study
BackgroundThe lumbar vertebra and paraspinal muscles play an important role in maintaining the stability of the lumbar spine. Therefore, the aim of...
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Immune checkpoint inhibitors-induced diabetes mellitus (review)
Immune checkpoint inhibitors (ICIs) have become extensively utilized in the early-stage treatment of various cancers, offering additional therapeutic...
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The impact of obesity on chronic oedema/lymphoedema of the leg – an international multicenter cross-sectional study (LIMPRINT)
Background/ObjectivesObesity and chronic oedema/lymphoedema are two distinct but related conditions, rarely investigated together. The aim was to...
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Ginsenoside Rb1 reduces oxidative/carbonyl stress damage and dysfunction of RyR2 in the heart of streptozotocin-induced diabetic rats
BackgroundOxidative stress may contribute to cardiac ryanodine receptor (RyR2) dysfunction in diabetic cardiomyopathy. Ginsenoside Rb1 (Rb1) is a...
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Clinical Outcomes in Patients with CKD and Rapid or Non-rapid eGFR Decline: A Report from the DISCOVER CKD Retrospective Cohort
IntroductionThis analysis examined the baseline characteristics and clinical outcomes of patients with chronic kidney disease (CKD) and rapid or...
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Associations amongst dynamic knee stiffness during gait, quadriceps stiffness, and the incidence of knee osteoarthritis over 24 months: a cohort study with a mediation analysis
BackgroundDecreased strength and increased stiffness of the quadriceps have been associated with a higher risk of develo** knee osteoarthritis (OA)...
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Development of a brief core set for knee dysfunction based on the International Classification of Functioning, Disability and Health: assessing construct validity and measurement potential
BackgroundThe comprehensive core set for knee dysfunction was developed to classify the functioning of people with any knee dysfunction. To be used...
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Feasibility of Indirect Treatment Comparisons Between Niraparib Plus Abiraterone Acetate and Other First-Line Poly ADP-Ribose Polymerase Inhibitor Treatment Regimens for Patients with BRCA1/2 Mutation-Positive Metastatic Castration-Resistant Prostate Cancer
IntroductionPoly(ADP-ribose) polymerase inhibitors (PARPi) are a novel option to treat patients with metastatic castration-resistant prostate cancer...
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Eteplirsen Treatment for Duchenne Muscular Dystrophy: A Qualitative Patient Experience Study
IntroductionDuchenne muscular dystrophy (DMD) is characterized by rapid functional decline. Current available treatment options aim to delay disease...
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Cost Offset of Dapagliflozin in the US Medicare Population with Cardio-Kidney Metabolic Syndrome
IntroductionCardiovascular-kidney-metabolic (CKM) syndrome is highly prevalent in the US Medicare population and is projected to increase further....
