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Aqp4a and Trpv4 mediate regulatory cell volume increase for swimming maintenance of marine fish spermatozoa
Volume regulation is essential for cell homeostasis and physiological function. Amongst the sensory molecules that have been associated with volume...
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In vivo photocontrol of orexin receptors with a nanomolar light-regulated analogue of orexin-B
Orexinergic neurons are critically involved in regulating arousal, wakefulness, and appetite. Their dysfunction has been associated with slee**...
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Computational discovery of AKT serine/threonine kinase 1 inhibitors through shape screening for rheumatoid arthritis intervention
Rheumatoid Arthritis (RA) is a chronic, symmetrical inflammatory autoimmune disorder characterized by painful, swollen synovitis and joint erosions,...
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Human cytomegalovirus infection impairs neural differentiation via repressing sterol regulatory element binding protein 2-mediated cholesterol biosynthesis
Congenital human cytomegalovirus (HCMV) infection is a major cause of abnormalities and disorders in the central nervous system (CNS) and/or the...
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Endogenous LXR signaling controls pulmonary surfactant homeostasis and prevents lung inflammation
Lung type 2 pneumocytes (T2Ps) and alveolar macrophages (AMs) play crucial roles in the synthesis, recycling and catabolism of surfactant material, a...
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Mechanistic and therapeutic perspectives of non-coding RNA-modulated apoptotic signaling in diabetic retinopathy
Diabetic retinopathy (DR), a significant and vision-endangering complication associated with diabetes mellitus, constitutes a substantial portion of...
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Horizontal gene transfer of the Mer operon is associated with large effects on the transcriptome and increased tolerance to mercury in nitrogen-fixing bacteria
BackgroundMercury (Hg) is highly toxic and has the potential to cause severe health problems for humans and foraging animals when transported into...
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Unconventional posttranslational modification in innate immunity
Pattern recognition receptors (PRRs) play a crucial role in innate immunity, and a complex network tightly controls their signaling cascades to...
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Low-dose ionizing radiation generates a hormetic response to modify lipid metabolism in Chlorella sorokiniana
Algal biomass is a viable source of chemicals and metabolites for various energy, nutritional, medicinal and agricultural uses. While stresses have...
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Ontogenetic variation in isotopic niche positions of aquatic consumers in boreal lakes
We used an extensive multispecies dataset to examine how C and N stable isotope ratios (δ 13 C and δ 15 N) of aquatic consumers varied with body size in...
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Contribution and control of microbial necromass carbon in wetland soils
Microbial necromass carbon (MNC) has been identified as an essential component of a persistent soil carbon pool. However, the contribution of MNC to...
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Origin recognition complex 6 overexpression promotes growth of glioma cells
The discovery of novel oncotargets for glioma is of immense significance. We here explored the expression patterns, biological functions, and...
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Functional characteristics and storage stability of hot air assisted radio frequency treated pearl millet
Nutricereals, pearl millet flour consumption is hardly limited to a few specific regions of the world owing to the development of early rancidity on...
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Demonstration for cold atmospheric pressure plasma jet operation and antibacterial action in microgravity
Cold atmospheric pressure plasma (ionized gas) is an innovative medical tool for the treatment of infected wounds thanks to its potential to...
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RECORD, a high-throughput, customizable system that unveils behavioral strategies leveraged by rodents during foraging-like decision-making
Translational studies benefit from experimental designs where laboratory organisms use human-relevant behaviors. One such behavior is...
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Iron Metabolism, Calcium, Magnesium and Trace Elements: A Review
Iron (Fe) is fundamental to life on earth. In the human body, it is both essential and harmful if above threshold. A similar balance applies to other...
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miRNAs that regulate apoptosis in breast cancer and cervical cancer
In today’s world, one of the main problems is cancer, which still has a long way to go to cure it, and it brings a lot of financial and emotional...
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Lhx4 surpasses its paralog Lhx3 in promoting the differentiation of spinal V2a interneurons
Paralog factors are considered to ensure the robustness of biological processes by providing redundant activity in cells where they are co-expressed....
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Unveiling the spatio-temporal variation of harmful algal bloom (HAB) species assemblages and their relationship with environmental factors in a tidal creek environment
The present study provides complementary information on the harmful algal bloom (HAB) species present in Manori Creek coastal water and tidal...
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A point cloud segmentation framework for image-based spatial transcriptomics
Recent progress in image-based spatial RNA profiling enables to spatially resolve tens to hundreds of distinct RNA species with high spatial...
