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Cortical Generators and Connections Underlying Phoneme Perception: A Mismatch Negativity and P300 Investigation
The cortical generators of the pure tone MMN and P300 have been thoroughly studied. Their nature and interaction with respect to phoneme perception,...
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Identification of purinergic system components in the venom of Bothrops mattogrossensis and the inhibitory effect of specioside extracted from Tabebuia aurea
Snake bites are a severe problem in the countryside of Brazil and are usually attributed to snakes of the genera Bothrops, Crotalus , and Lachesis ....
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Plasma biomarkers of amyloid, tau, axonal, and neuroinflammation pathologies in dementia with Lewy bodies
BackgroundIncreasing evidence supports the use of plasma biomarkers of amyloid, tau, neurodegeneration, and neuroinflammation for diagnosis of...
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Multi-scale modeling to investigate the effects of transcranial magnetic stimulation on morphologically-realistic neuron with depression
Transcranial magnetic stimulation (TMS) is a non-invasive neuromodulation technique to activate or inhibit the activity of neurons, and thereby...
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Sex-dependent APOE4 neutrophil–microglia interactions drive cognitive impairment in Alzheimer’s disease
APOE4 is the strongest genetic risk factor for Alzheimer’s disease (AD), with increased odds ratios in female carriers. Targeting amyloid plaques...
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Building genomic capacity for precision health in Africa
The African continent is poised to have a pivotal role in the global population landscape, with the United Nations projecting a population of 2.5...
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Central nervous system-associated macrophages modulate the immune response following stroke in aged mice
Age is a major nonmodifiable risk factor for ischemic stroke. Central nervous system-associated macrophages (CAMs) are resident immune cells located...
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Revisiting reactive oxygen species production in hypoxia
Cellular responses to hypoxia are crucial in various physiological and pathophysiological contexts and have thus been extensively studied. This has...
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Morphological and Molecular Characteristics of Perineuronal Nets in the Human Prefrontal Cortex—A Possible Link to Microcircuitry Specialization
Perineuronal nets (PNNs) are a type of extracellular matrix (ECM) that play a significant role in synaptic activity and plasticity of interneurons in...
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Identifying longitudinal cognitive resilience from cross-sectional amyloid, tau, and neurodegeneration
BackgroundLeveraging Alzheimer’s disease (AD) imaging biomarkers and longitudinal cognitive data may allow us to establish evidence of cognitive...
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Constraints on the subsecond modulation of striatal dynamics by physiological dopamine signaling
Dopaminergic neurons play a crucial role in associative learning, but their capacity to regulate behavior on subsecond timescales remains debated. It...
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From Lab Bench to Hope: Emerging Gene Therapies in Clinical Trials for Alzheimer’s Disease
Alzheimer’s disease is a progressive neurodegenerative disorder that affects memory and cognitive abilities, affecting millions of people around the...
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Heat-related illness and dementia: a study integrating epidemiological and experimental evidence
BackgroundHeat-related illness (HRI) is commonly considered an acute condition, and its potential long-term consequences are not well understood. We...
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Ectonucleotidase inhibitors: targeting signaling pathways for therapeutic advancement—an in-depth review
Ectonucleotidase inhibitors are a family of pharmacological drugs that, by selectively targeting ectonucleotidases, are essential in altering...
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Nutrition guidance within a multimodal intervention improves diet quality in prodromal Alzheimer’s disease: Multimodal Preventive Trial for Alzheimer’s Disease (MIND-ADmini)
BackgroundMultimodal lifestyle interventions can benefit overall health, including cognition, in populations at-risk for dementia. However, little is...
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Multiple Roles of Apolipoprotein E4 in Oxidative Lipid Metabolism and Ferroptosis During the Pathogenesis of Alzheimer’s Disease
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease worldwide and has a great socio-economic impact. Modified oxidative lipid...
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Choroid plexus volume as a novel candidate neuroimaging marker of the Alzheimer’s continuum
BackgroundEnlarged choroid plexus (ChP) volume has been reported in patients with Alzheimer’s disease (AD) and inversely correlated with cognitive...
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A feature-specific prediction error model explains dopaminergic heterogeneity
The hypothesis that midbrain dopamine (DA) neurons broadcast a reward prediction error (RPE) is among the great successes of computational...
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A unified metric of human immune health
Immunological health has been challenging to characterize but could be defined as the absence of immune pathology. While shared features of some...
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The Possible Neuroprotective Effect of Caffeic Acid on Cognitive Changes and Anxiety-Like Behavior Occurring in Young Rats Fed on High-Fat Diet and Exposed to Chronic Stress: Role of β-Catenin/GSK-3B Pathway
Lifestyle influences physical and cognitive development during the period of adolescence greatly. The most important of these lifestyle factors are...
