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Embedding community and public voices in co-created solutions to mitigate antimicrobial resistance (AMR) in Thailand using the ‘Responsive Dialogues’ public engagement framework
The use of antimicrobials in Thailand has been reported as one of the highest in the world in human and animal sectors. Our engagement project aimed...
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Extension of efficacy range for targeted malaria-elimination interventions due to spillover effects
Malaria-elimination interventions aim to extinguish hotspots and prevent transmission to nearby areas. Here, we re-analyzed a cluster-randomized...
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Basal release of 6-cyanodopamine from rat isolated vas deferens and its role on the tissue contractility
6-Cyanodopamine is a novel catecholamine released from rabbit isolated heart. However, it is not known whether this catecholamine presents any...
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Evaluation and mitigation of the limitations of large language models in clinical decision-making
Clinical decision-making is one of the most impactful parts of a physician’s responsibilities and stands to benefit greatly from artificial...
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Harnessing EHR data for health research
With the increasing availability of rich, longitudinal, real-world clinical data recorded in electronic health records (EHRs) for millions of...
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The 60-year evolution of lipid nanoparticles for nucleic acid delivery
Delivery of genetic information to the interior of target cells in vivo has been a major challenge facing gene therapies. This barrier is now being...
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Potent synergy and sustained bactericidal activity of polymyxins combined with Gram-positive only class of antibiotics versus four Gram-negative bacteria
BackgroundGram-negative bacteria (GNB) are becoming increasingly resistant to a wide variety of antibiotics. There are currently limited treatments...
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Multiple myeloma: signaling pathways and targeted therapy
Multiple myeloma (MM) is the second most common hematological malignancy of plasma cells, characterized by osteolytic bone lesions, anemia,...
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Colistin-, cefepime-, and levofloxacin-resistant Salmonella enterica serovars isolated from Egyptian chicken carcasses
ObjectivesThe emergence of multidrug-resistant (MDR) Salmonella strains, especially resistant ones toward critically important antimicrobial classes...
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AI-based differential diagnosis of dementia etiologies on multimodal data
Differential diagnosis of dementia remains a challenge in neurology due to symptom overlap across etiologies, yet it is crucial for formulating...
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ATR, CHK1 and WEE1 inhibitors cause homologous recombination repair deficiency to induce synthetic lethality with PARP inhibitors
PurposePARP inhibitors (PARPi) are effective in homologous recombination repair (HRR) defective (HRD) cancers. To (re)sensitise HRR proficient (HRP)...
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Building genomic capacity for precision health in Africa
The African continent is poised to have a pivotal role in the global population landscape, with the United Nations projecting a population of 2.5...
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Sex-dependent APOE4 neutrophil–microglia interactions drive cognitive impairment in Alzheimer’s disease
APOE4 is the strongest genetic risk factor for Alzheimer’s disease (AD), with increased odds ratios in female carriers. Targeting amyloid plaques...
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Genomic characterization of Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae (KPC-Kp) strains circulating in three university hospitals in Northern Italy over three years
ObjectivesGenomic surveillance of Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae (KPC-Kp) is crucial for virulence,...
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Systematic Review on Flow Cytometry as a Versatile Tool for Disease Diagnosis
Purpose of ReviewQuantification and identification of cell fate remain to be the most important step within research and diagnostic laboratories.With...
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Tracking the Plasma C-Terminal Agrin Fragment as a Biomarker of Neuromuscular Decline in 18- to 87-Year-Old Men
ObjectivesPlasma C-terminal agrin-fragment-22 (CAF22), a breakdown product of neuromuscular junction, is a potential biomarker of muscle loss....
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Revisiting reactive oxygen species production in hypoxia
Cellular responses to hypoxia are crucial in various physiological and pathophysiological contexts and have thus been extensively studied. This has...
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A unified metric of human immune health
Immunological health has been challenging to characterize but could be defined as the absence of immune pathology. While shared features of some...
