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  1. No Access

    Article

    Obesity-associated inflammation induces androgenic to estrogenic switch in the prostate gland

    Our patient cohort revealed that obesity is strongly associated with steroid-5α reductase type 2 (SRD5A2) promoter methylation and reduced protein expression. The underlying mechanism of prostatic growth in this ...

    Bichen Xue, Shulin Wu, Christina Sharkey… in Prostate Cancer and Prostatic Diseases (2020)

  2. Article

    Open Access

    Insulin resistance is associated with epigenetic and genetic regulation of mitochondrial DNA in obese humans

    Mitochondrial alterations have been observed in subjects with metabolic disorders such as obesity and diabetes. Studies on animal models and cell cultures suggest aberrant glucose and lipid levels, and impaire...

    Louise D. Zheng, Leah E. Linarelli, Longhua Liu, Sarah S. Wall… in Clinical Epigenetics (2015)

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    Article

    The AKTion in non-canonical insulin signaling

    The kinase AKT has been regarded as an obligate intermediate in the insulin signaling pathway that suppresses glucose production by inhibiting the transcription factor forkhead box O1 (FoxO1) after meals. A ne...

    Zhiyong Cheng, Morris F White in Nature Medicine (2012)

  4. No Access

    Article

    Foxo1 integrates insulin signaling with mitochondrial function in the liver

    Hepatic insulin resistance is often associated with mitochondrial dysfunction, leading to defects in cellular activity. Morris White and his colleagues have now found that continued activity of the transcripti...

    Zhiyong Cheng, Shaodong Guo, Kyle Copps, **aochen Dong, Ramya Kollipara… in Nature Medicine (2009)