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Article
Particle flow characteristics in a gas–solid fluidized bed: a microscopic perspective by coupled CFD–DEM approach
In a dense gas–solid fluidized bed, the microscopic quantities, including forces and energy of particles, directly determine their macroscopic motion in space. In this work, the CFD–DEM coupling approach is us...
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Article
Recent Advances and Perspectives of CFD–DEM Simulation in Fluidized Bed
The coupling of computational fluid dynamics (CFD) and discrete element method (DEM) has become an important method for studying dense fluidized beds. Since DEM can track the motion behavior of each particle i...
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Article
Open AccessMacrocyclization of linear molecules by deep learning to facilitate macrocyclic drug candidates discovery
Interest in macrocycles as potential therapeutic agents has increased rapidly. Macrocyclization of bioactive acyclic molecules provides a potential avenue to yield novel chemical scaffolds, which can contribut...
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Article
Open AccessCorrection to: Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2
In the original publication the author’s name ‘Dimitri Lavillete’ is published incorrectly. The correct author name should be spelt as ‘Dimitri Lavillette’ is provided in this correction.
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Article
Image decomposition based on the adaptive direction total variation and \(\mathbb {G}\) -norm regularization
To improve the decomposition quality, it is very important to describe the local structure of the image in the proposed model. This fact motivates us to improve the Meyer’s decomposition model via coupling one...
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Article
Open AccessCorrection to: Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2
In the original publication there are few errors in Figure 1. The correct Figure 1 is provided in this correction
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Article
Hydrocyclone separation performance influenced by feeding solid concentration and correcting separation size
Operation parameters restrict the performance of hydrocyclone in offshore platforms. Based on the computational fluid dynamics (CFD) software Fluent and the similarity parameter criterion experiment, the numer...
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Article
Open AccessNovel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2
Emerging and re-emerging RNA viruses occasionally cause epidemics and pandemics worldwide, such as the on-going outbreak of the novel coronavirus SARS-CoV-2. Herein, we identified two potent inhibitors of huma...
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Article
In situ synthesis of porous LiNi0.5Co0.2Mn0.3O2 tubular-fiber as high-performance cathode materials for Li-ion batteries
Hollow structural materials exhibit strong advantages for application in electrode materials. Herein, we report an in situ synthesis of hollow tubular-fiber LiNi0.5Co0.2Mn0.3O2 (HFNCM523) prepared via electrospin...
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Article
The Effect of Money-Back Guarantee and Customer Value on Dual-Channel Supply Chain
This paper investigates the effect of money-back guarantee (MBG) and customer value on dual-channel supply chain. Manufacturer could produce and sell old generation product by direct channel to compete with ne...
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Article
Naringenin inhibits migration of breast cancer cells via inflammatory and apoptosis cell signaling pathways
Naringenin, a flavonoid compound, has a wide variety of uses in the pharmaceutical industry for its antioxidant and anti-inflammatory potential.
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Article
Slowly oscillating solutions in a class of second-order discontinuous delayed systems
This paper investigates the dynamics of oscillations for a class of second-order discontinuous differential equations with time delay. First, by analyzing an implicit function which is determined by a crucial ...
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Article
RSK2 is required for TRAF6 phosphorylation-mediated colon inflammation
Inflammation is a complex biological host reaction to tissue damage, infection and trauma. Extensive study of the inflammatory response has led to the identification of several protein kinases that are essenti...
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Article
Image post-processed approaches for cavitating flow in orifice plate
A comprehensive investigation on cavitating flow and cavitation-induced erosion was performed experimentally in an orifice plate system. Three image post-processed approaches were applied to analyze the test d...
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Article
Open AccessStructure-Guided Design of C4-alkyl-1,4-dihydro-2H-pyrimido[4,5-d][1,3]oxazin-2-ones as Potent and Mutant-Selective Epidermal Growth Factor Receptor (EGFR) L858R/T790M Inhibitors
Epidermal growth factor receptor (EGFR) T790M acquired drug-resistance mutation has become a major clinical challenge for the therapy of non-small cell lung cancer. Here, we applied a structure-guided approach...
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Article
Open AccessRational Design of Benzylidenehydrazinyl-Substituted Thiazole Derivatives as Potent Inhibitors of Human Dihydroorotate Dehydrogenase with in Vivo Anti-arthritic Activity
Human dihydroorotate dehydrogenase (hDHODH) is an attractive therapeutic target for the treatment of rheumatoid arthritis, transplant rejection and other autoimmune diseases. Based on the X-ray structure of hDHOD...
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Article
Cluster, local and complete synchronization in coupled neural networks with mixed delays and nonlinear coupling
In this paper, synchronization analysis is investigated for an array of hybrid coupled neural networks with discrete time-varying delays, distributed time-varying delays and nonlinear coupling. By utilizing a ...
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Article
Derivatives of benzothiadiazole-7-carboxylates: synthesis and biological activity
Salicylic acid (SA) and methyl jasmonate (MJ) are important plant signal molecules to cause systemic acquired resistance (SAR), while it’s reported that they also have wide spectrum antitumor activities. Benzothi...