40 Result(s)
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Article
Zhe-**ong Lian
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Article
Assembling zwitterionic, water-soluble porphyrin and its biological studies
A kind of zwitterionic water-soluble porphyrin 5-(N-trimethyl-4-aminiumphenyl)-10, 15, 20-tri (4-sulfonatephenyl) porphyrin trisammonium salt, has been synthesized. Its biological studies, interactions with DN...
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Comparative Proteomics Analysis of Cerebrospinal Fluid of Patients with Guillain–Barré Syndrome
To better understand the pathophysiologic mechanisms underlying Guillain–Barré syndrome (GBS), Comparative proteomic analysis of cerebrospinal fluid (CSF) between patients with GBS (the experiment group) and c...
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DGR: dynamic gradient-based routing protocol for unbalanced and persistent data transmission in wireless sensor and actor networks
This paper is concerned with the routing protocol design for large-scale wireless sensor and actor networks (WSANs). The actor-sensor-actor communication (ASAC) strategy is first proposed to guarantee the reli...
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Interlayer shear strength of single crystalline graphite
Reported values (0.2 MPa–7.0 GPa) of the interlayer shear strength (ISS) of graphite are very dispersed. The main challenge to obtain a reliable value of the ISS using conventional measuring methods was the un...
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Traditional Chinese Medicine and Immune Regulation
Traditional Chinese medicines (TCMs) have a long history in Asian countries and are traditionally used to prevent and treat a variety of diseases. The rising interest in TCMs in recent years is reflected in bo...
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Open AccessRETRACTED ARTICLE: Cardioprotective activity of placental growth factor in a rat model of acute myocardial infarction: nanoparticle-based delivery versus direct myocardial injection
To comparatively evaluate the cardioprotective activity of placental growth factor (PGF) delivered through direct injection and a nanoparticle-based system respectively and to study the underlying mechanisms i...
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Open AccessRetraction Note: Cardioprotective activity of placental growth factor in a rat model of acute myocardial infarction: nanoparticle-based delivery versus direct myocardial injection
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Association of genetic polymorphisms of interleukins with gastric cancer and precancerous gastric lesions in a high-risk Chinese population
Helicobacter pylori (H. pylori) infection and cytokine-mediated inflammatory responses play important roles in gastric cancer (GC) pathogenesis. To investigate an association between gene...
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Epigenetics and Primary Biliary Cirrhosis: a Comprehensive Review and Implications for Autoimmunity
Primary biliary cirrhosis (PBC) is a chronic inflammatory autoimmune disease that develops based upon the interaction of genetic and environmental factors. Recent genome-wide association studies (GWAS) have id...
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Open AccessBlock of both TGF-β and IL-2 signaling impedes Neurophilin-1+ regulatory T cell and follicular regulatory T cell development
Understanding the mechanisms that lead to autoimmunity is critical for defining potential therapeutic pathways. In this regard there have been considerable efforts in investigating the interacting roles of TGF-β ...
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Forkhead Box O1 Regulates Macrophage Polarization Following Staphylococcus aureus Infection: Experimental Murine Data and Review of the Literature
The functions of macrophages that lead to effective host responses are critical for protection against Staphylococcus aureus. Deep tissue-invading S. aureus initially countered by macrophages trigger macrophage a...
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Open AccessModulation of liver regeneration via myeloid PTEN deficiency
Molecular mechanisms that modulate liver regeneration are of critical importance for a number of hepatic disorders. Kupffer cells and natural killer (NK) cells are two cell subsets indispensable for liver rege...
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Open AccessCut-off optimization for 13C-urea breath test in a community-based trial by mathematic, histology and serology approach
The performance of diagnostic tests in intervention trials of Helicobacter pylori (H.pylori) eradication is crucial, since even minor inaccuracies can have major impact. To determine the cut-off point for 13C-ure...
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Open AccessA Mouse Model of Autoimmune Cholangitis via Syngeneic Bile Duct Protein Immunization
Primary biliary cholangitis (PBC) is an autoimmune liver disease characterized by the destruction of interlobular biliary ductules, which progressively leads to cholestasis, hepatic fibrosis, cirrhosis, and ev...
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Article
FoxO1 is a regulator of MHC-II expression and anti-tumor effect of tumor-associated macrophages
Macrophages are a critical component in host immune responses against tumor. In this work we investigated the role of forkhead box O1 (FoxO1) in the transcriptional regulation in macrophages, which affects the...
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Creation of a rabbit model for intrauterine adhesions using electrothermal injury
The pathogenesis and therapeutic treatment of intrauterine adhesions (IUAs) remain unsolved, highlighting the need for stable and effective experimental animal models. In this study, uterine electrocoagulation...
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Optimized nanoparticle-mediated delivery of CRISPR-Cas9 system for B cell intervention
B cells exert multiple effector functions, and dysfunctions of B cells often lead to initiation and progression of diseases, including autoimmune and inflammatory diseases. Therefore, B cell intervention may b...
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Open AccessPotent immunomodulation and angiogenic effects of mesenchymal stem cells versus cardiomyocytes derived from pluripotent stem cells for treatment of heart failure
Optimal cell type as cell-based therapies for heart failure (HF) remains unclear. We sought to compare the safety and efficacy of direct intramyocardial transplantation of human embryonic stem cell-derived car...
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Liver-resident NK cells suppress autoimmune cholangitis and limit the proliferation of CD4+ T cells
Liver-resident NK cells are distinct from conventional NK cells and play an important role in the maintenance of liver homeostasis. How liver-resident NK cells participate in autoimmune cholangitis remains unc...
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Recent research and development of thick CVD tungsten coatings for fusion application
As the interface closest to the edge plasma of a fusion reactor reacting deuterium (D) and tritium (T), plasma-facing material (PFM) need to withstand extreme service conditions with the high particle flux, hi...
