19 Result(s)

Article

RETRACTED ARTICLE: Cardioprotective activity of placental growth factor in a rat model of acute myocardial infarction: nanoparticle-based delivery versus direct myocardial injection

To comparatively evaluate the cardioprotective activity of placental growth factor (PGF) delivered through direct injection and a nanoparticle-based system respectively and to study the underlying mechanisms i...

Zhe-xin Lu, Li-li Mao, Feng Lian, Jun He, Wen-tian Zhang… in BMC Cardiovascular Disorders (2014)

Article

Retraction Note: Cardioprotective activity of placental growth factor in a rat model of acute myocardial infarction: nanoparticle-based delivery versus direct myocardial injection

Zhe-xin Lu, Li-li Mao, Feng Lian, Jun He, Wen-tian Zhang… in BMC Cardiovascular Disorders (2015)

Article

Block of both TGF-β and IL-2 signaling impedes Neurophilin-1⁺ regulatory T cell and follicular regulatory T cell development

Understanding the mechanisms that lead to autoimmunity is critical for defining potential therapeutic pathways. In this regard there have been considerable efforts in investigating the interacting roles of TGF-β ...

Liang Li, Shu-Han Yang, Yuan Yao, Yu-Qing **e, Yan-Qing Yang… in Cell Death & Disease (2016)

Article

Modulation of liver regeneration via myeloid PTEN deficiency

Molecular mechanisms that modulate liver regeneration are of critical importance for a number of hepatic disorders. Kupffer cells and natural killer (NK) cells are two cell subsets indispensable for liver rege...

Wen-Tao Ma, Yan-Jie Jia, Qing-Zhi Liu, Yan-Qing Yang, **g-Bo Yang… in Cell Death & Disease (2017)

Article

Cut-off optimization for ¹³C-urea breath test in a community-based trial by mathematic, histology and serology approach

The performance of diagnostic tests in intervention trials of Helicobacter pylori (H.pylori) eradication is crucial, since even minor inaccuracies can have major impact. To determine the cut-off point for ¹³C-ure...

Zhe-Xuan Li, Lei-Lei Huang, Cong Liu, Luca Formichella, Yang Zhang… in Scientific Reports (2017)

Article

A Mouse Model of Autoimmune Cholangitis via Syngeneic Bile Duct Protein Immunization

Primary biliary cholangitis (PBC) is an autoimmune liver disease characterized by the destruction of interlobular biliary ductules, which progressively leads to cholestasis, hepatic fibrosis, cirrhosis, and ev...

Wen-Tao Ma, Qing-Zhi Liu, **g-Bo Yang, Yan-Qing Yang, Zhi-Bin Zhao… in Scientific Reports (2017)

Article

Potent immunomodulation and angiogenic effects of mesenchymal stem cells versus cardiomyocytes derived from pluripotent stem cells for treatment of heart failure

Optimal cell type as cell-based therapies for heart failure (HF) remains unclear. We sought to compare the safety and efficacy of direct intramyocardial transplantation of human embryonic stem cell-derived car...

Songyan Liao, Yuelin Zhang, Sherwin Ting, Zhe Zhen, Fan Luo… in Stem Cell Research & Therapy (2019)

Article

Multi-omics analysis identifies FoxO1 as a regulator of macrophage function through metabolic reprogramming

Macrophages are plastic cells that can switch among different states according to bioenergetic or biosynthetic requirements. Our previous work demonstrated that the transcription factor Forkhead Box Protein 1 (Fo...

Kai Yan, Tian-Tian Da, Zhen-Hua Bian, Yi He, Meng-Chu Liu… in Cell Death & Disease (2020)

Article

Effect of mould baffle technology on stray grain formation in single crystal blades by integral fabrication based on 3D printing

Stray grains, the most serious casting defect, mainly occur in the platform because of the abrupt transition of the cross-section in the directional solidification of superalloy single-crystal blades. A new mo...

Zhe-feng Liu, Kai Miao, Wei-bo Lian, Zhong-liang Lu, Chen Yi, Di-chen Li in China Foundry (2021)

Article

Chromatin accessibility analysis identifies the transcription factor ETV5 as a suppressor of adipose tissue macrophage activation in obesity

Activation of adipose tissue macrophages (ATMs) contributes to chronic inflammation and insulin resistance in obesity. However, the transcriptional regulatory machinery involved in ATM activation during the de...

Ren-Dong Hu, Wen Zhang, Liang Li, Zu-Qi Zuo, Min Ma, **-Fen Ma… in Cell Death & Disease (2021)

Article

Gene co-expression network based on part mutual information for gene-to-gene relationship and gene-cancer correlation analysis

Finding correlation patterns is an important goal of analyzing biological data. Currently available methods for correlation analysis mainly use non-direct associations, such as the Pearson correlation coeffici...

Yi-Hua Jiang, Jie Long, Zhi-Bin Zhao, Liang Li, Zhe-**ong Lian… in BMC Bioinformatics (2022)

Article

Gradually shifting clinical phenomics in migraine spectrum: a cross-sectional, multicenter study of 5438 patients

The aim of the study was to investigate whether MwoA and MwA are different manifestations of a single disease, distinct clinical entities, or located at two poles of a spectrum.

Ye Ran, Ziming Yin, Yajun Lian, Yanmei Xu, Yajie Li… in The Journal of Headache and Pain (2022)

Article

Notch signaling mutations increase intra-tumor chemokine expression and predict response to immunotherapy in colorectal cancer

The Notch signaling mutation is associated with enhanced anti-tumor immune response in colorectal cancer (CRC). In this study, we aim to investigate the underlying mechanism and the predictive potential of Not...

Fei Wang, Chuan Huang, Jie Long, Zhi-Bin Zhao, Hai-Qing Ma, Xue-Qing Yao… in BMC Cancer (2022)

Article

Comprehensive transcriptomic profiling and mutational landscape of primary gastric linitis plastica

Primary gastric linitis plastica (GLP) is a distinct phenotype of gastric cancer with poor survival. Comprehensive molecular profiles and putative therapeutic targets of GLP remain undetermined.

Zhu Liu, Lian-Lian Hong, **-Sen Zheng, Zhe-Nan Ling, Zhi-Long Zhang… in Gastric Cancer (2023)

Article

Correction: Comprehensive transcriptomic profiling and mutational landscape of primary gastric linitis plastica

Zhu Liu, Lian-Lian Hong, **-Sen Zheng, Zhe-Nan Ling, Zhi-Long Zhang… in Gastric Cancer (2023)

Article

Efficacy and safety profile of angiotensin receptor neprilysin inhibitors in the management of heart failure: a systematic review and meta-analysis of randomized controlled trials

Several guidelines have recommended the use of angiotensin receptor neprilysin inhibitors (ARNIs) as replacement for angiotensin-converting enzyme inhibitors in the management of heart failure. Till date, ther...

Juan Gao, Cong Zhao, Wen-Zhong Zhang, Song Liu, Hui **n… in Heart Failure Reviews (2023)

Article

Systematic pan-cancer analyses of the potential function of the Golgi scaffold protein PAQR3

Progesterone and AdipoQ Receptor 3 (PAQR3) is a member of the AdipoQ receptor. Our previous studies have found that PAQR3 plays a role as a candidate inhibitor in cardiac adenocarcinoma, breast cancer, gastric...

Zhe-Nan Ling, Lian-Lian Hong, Jian Wu, Zhi-Qiang Ling in Scientific Reports (2024)

Article

Targeting pathogenic CD8⁺ tissue-resident T cells with chimeric antigen receptor therapy in murine autoimmune cholangitis

Primary biliary cholangitis (PBC) is a cholestatic autoimmune liver disease characterized by autoreactive T cell response against intrahepatic small bile ducts. Here, we use Il12b^-/-Il2ra^-/- mice (DKO mice) as a ...

Hao-**an Zhu, Shu-Han Yang, Cai-Yue Gao, Zhen-Hua Bian… in Nature Communications (2024)

Article

Probabilistic sunspot predictions with a gated recurrent units-based combined model guided by pinball loss

Sunspots play a crucial role in both weather forecasting and the monitoring of solar storms. In this work, we propose a novel combined model for sunspot prediction using improved gated recurrent units (GRU) gu...

Zhesen Cui, Zhe Ding, **g Xu, Shaotong Zhang, **ran Wu, Wei Lian in Scientific Reports (2024)