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Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

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  1. Article

    Open Access

    Ultrahigh-Gain Photodetectors Based on Atomically Thin Graphene-MoS2 Heterostructures

    Due to its high carrier mobility, broadband absorption and fast response time, the semi-metallic graphene is attractive for optoelectronics. Another two-dimensional semiconducting material molybdenum disulfide...

    Wen**g Zhang, Chih-Piao Chuu, **g-Kai Huang, Chang-Hsiao Chen in Scientific Reports (2014)

  2. Article

    Open Access

    In situ observation of step-edge in-plane growth of graphene in a STEM

    It is extremely difficult to control the growth orientation of the graphene layer in comparison to Si or III–V semiconductors. Here we report a direct observation of graphene growth and domain boundary formati...

    Zheng Liu, Yung-Chang Lin, Chun-Chieh Lu, Chao-Hui Yeh in Nature Communications (2014)

  3. Article

    Open Access

    The effect of fluorescent nanodiamonds on neuronal survival and morphogenesis

    Nanodiamond (ND) has emerged as a promising carbon nanomaterial for therapeutic applications. In previous studies, ND has been reported to have outstanding biocompatibility and high uptake rate in various cell...

    Yung-An Huang, Chun-Wei Kao, Kuang-Kai Liu, Hou-Syun Huang in Scientific Reports (2014)

  4. Article

    Open Access

    Achieving planar plasmonic subwavelength resolution using alternately arranged insulator-metal and insulator-insulator-metal composite structures

    This work develops and analyzes a planar subwavelength device with the ability of one-dimensional resolution at visible frequencies that is based on alternately arranged insulator-metal (IM) and insulator-insu...

    Bo Han Cheng, Kai Jiun Chang, Yung-Chiang Lan, Din ** Tsai in Scientific Reports (2015)

  5. Article

    Open Access

    Sirtinol Inhibits Neutrophil Elastase Activity and Attenuates Lipopolysaccharide-Mediated Acute Lung Injury in Mice

    Enhanced activity of neutrophil elastase leads to a protease–antiprotease imbalance and plays an essential pathogenic role in acute lung injury (ALI) and acute respiratory distress syndrome. We assayed the pha...

    Yung-Fong Tsai, Huang-** Yu, Wen-Yi Chang, Fu-Chao Liu in Scientific Reports (2015)

  6. Article

    Open Access

    Three-fold rotational defects in two-dimensional transition metal dichalcogenides

    As defects frequently govern the properties of crystalline solids, the precise microscopic knowledge of defect atomic structure is of fundamental importance. We report a new class of point defects in single-la...

    Yung-Chang Lin, Torbjörn Björkman, Hannu-Pekka Komsa, Po-Yuan Teng in Nature Communications (2015)

  7. Article

    Open Access

    A hybrid-membrane migration method to isolate high-purity adipose-derived stem cells from fat tissues

    Human adipose-derived stem cells (hADSCs) exhibit heterogeneous characteristics, indicating various genotypes and differentiation abilities. The isolated hADSCs can possess different purity levels and divergen...

    Akon Higuchi, Ching-Tang Wang, Qing-Dong Ling, Henry Hsin-chung Lee in Scientific Reports (2015)

  8. Article

    Open Access

    Nonautophagic cytoplasmic vacuolation death induction in human PC-3M prostate cancer by curcumin through reactive oxygen species -mediated endoplasmic reticulum stress

    The antiapoptotic and antiautophagic abilities of cancer cells constitute a major challenge for anticancer drug treatment. Strategies for triggering nonapoptotic or nonautophagic cell death may improve therape...

    Wei-Jiunn Lee, Ming-Hsien Chien, Jyh-Ming Chow, Junn-Liang Chang in Scientific Reports (2015)

  9. Article

    Open Access

    Characterization of proteins regulated by interleukin-4 in 3T3-L1 adipocytes

    Obesity is closely associated with metabolic syndrome, type 2 diabetes mellitus (T2DM) and cardiovascular diseases. Our previous reports uncover the significant associations between interleukin-4 (IL-4)/IL-4 rece...

    Ming-Yuh Shiau, Hsu-Feng Lu, Yih-Hsin Chang, Yen-Chih Chiu, Yung-Luen Shih in SpringerPlus (2015)

  10. Article

    Open Access

    Homology modeling of DFG-in FMS-like tyrosine kinase 3 (FLT3) and structure-based virtual screening for inhibitor identification

    The inhibition of FMS-like tyrosine kinase 3 (FLT3) activity using small-molecule inhibitors has emerged as a target-based alternative to traditional chemotherapy for the treatment of acute myeloid leukemia (A...

    Yi-Yu Ke, Vivek Kumar Singh, Mohane Selvaraj Coumar, Yung Chang Hsu in Scientific Reports (2015)

  11. Article

    Open Access

    Apoptosis of tumor infiltrating effector TIM-3+CD8+ T cells in colon cancer

    TIM-3 functions to enforce CD8+ T cell exhaustion, a dysfunctional state associated with the tolerization of tumor microenvironment. Here we report apoptosis of IFN-γ competent TIM-3+ population of tumor-infil...

    Chiao-Wen Kang, Avijit Dutta, Li-Yuan Chang, Jayashri Mahalingam in Scientific Reports (2015)

  12. Article

    Open Access

    Magnetically controlled planar hyperbolic metamaterials for subwavelength resolution

    Breaking diffraction limitation is one of the most important issues and still remains to be solved for the demand of high-density optoelectronic components, especially for the photolithography industry. Since ...

    Bo Han Cheng, Hong Wen Chen, Kai Jiun Chang, Yung-Chiang Lan in Scientific Reports (2015)

  13. Article

    Open Access

    Growing GaN LEDs on amorphous SiC buffer with variable C/Si compositions

    The epitaxy of high-power gallium nitride (GaN) light-emitting diode (LED) on amorphous silicon carbide (a-SixC1−x) buffer is demonstrated. The a-SixC1−x buffers with different nonstoichiometric C/Si composition ...

    Chih-Hsien Cheng, An-Jye Tzou, Jung-Hung Chang, Yu-Chieh Chi in Scientific Reports (2016)

  14. Article

    Open Access

    Whole genome sequencing revealed host adaptation-focused genomic plasticity of pathogenic Leptospira

    Leptospirosis, caused by pathogenic Leptospira spp., has recently been recognized as an emerging infectious disease worldwide. Despite its severity and global importance, knowledge about the molecular pathogenesi...

    Yinghua Xu, Yongzhang Zhu, Yuezhu Wang, Yung-Fu Chang, Ying Zhang in Scientific Reports (2016)

  15. Article

    Open Access

    Thermoelectric Power in Bilayer Graphene Device with Ionic Liquid Gating

    The quest for materials showing large thermoelectric power has long been one of the important subjects in material science and technology. Such materials have great potential for thermoelectric cooling and als...

    Yung-Yu Chien, Hongtao Yuan, Chang-Ran Wang, Wei-Li Lee in Scientific Reports (2016)

  16. Article

    Open Access

    Acute Kidney Injury Classification for Critically Ill Cirrhotic Patients: A Comparison of the KDIGO, AKIN and RIFLE Classifications

    Critically ill cirrhotic patients have high mortality rates, particularly when they present with acute kidney injury (AKI) on admission. The Kidney Disease: Improving Global Outcomes (KDIGO) group aimed to sta...

    Heng-Chih Pan, Yu-Shan Chien, Chang-Chyi Jenq, Ming-Hung Tsai in Scientific Reports (2016)

  17. Article

    Open Access

    Helical Majorana fermions in -wave topological superconductivity of doped correlated quantum spin Hall insulators

    There has been growing interest in searching for exotic self-conjugate, charge-neutral low-energy fermionic quasi-particles, known as Majorana fermions (MFs) in solid state systems. Their signatures have been ...

    Shih-Jye Sun, Chung-Hou Chung, Yung-Yeh Chang, Wei-Feng Tsai in Scientific Reports (2016)

  18. Article

    Open Access

    Induction of IL-25 secretion from tumour-associated fibroblasts suppresses mammary tumour metastasis

    Tumour-associated fibroblasts (TAFs), as a functionally supportive microenvironment, play an essential role in tumour progression. Here we investigate the role of IL-25, an endogenous anticancer factor secrete...

    Shu-Yi Yin, Feng-Yin Jian, Yung-Hsiang Chen, Shih-Chang Chien in Nature Communications (2016)

  19. Article

    Open Access

    Giant photoluminescence enhancement in tungsten-diselenide–gold plasmonic hybrid structures

    Impressive properties arise from the atomically thin nature of transition metal dichalcogenide two-dimensional materials. However, being atomically thin limits their optical absorption or emission. Hence, enha...

    Zhuo Wang, Zhaogang Dong, Yinghong Gu, Yung-Huang Chang, Lei Zhang in Nature Communications (2016)

  20. Article

    Open Access

    Association between previous history of gout attack and risk of deep vein thrombosis - a nationwide population-based cohort study

    Although the association of hyperuricemia and cardiovascular diseases is well established by previous research studies, the relationship between gout and deep vein thrombosis (DVT) remains unclear. We conducte...

    Chun-Chih Chiu, Yung-Tai Chen, Chien-Yi Hsu, Chun-Chin Chang in Scientific Reports (2016)

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