-
Article
Application study of DTI combined with ASL in the crossed cerebellar diaschisis after subacute cerebral hemorrhage
To study the value of 3.0T magnetic resonance imaging with diffusion tensor imaging (DTI) and 3D-arterial spin labeling (ASL) perfusion imaging in the diagnosis of the crossed cerebellar diaschisis (CCD) after...
-
Article
Clinical and imaging features of diabetic striatopathy: report of 6 cases and literature review
To explore the clinical manifestations, diagnosis, treatment, and pathogenesis of diabetic striatopathy (DS) to improve the understanding of the disease and avoid misdiagnosis or underdiagnosis.
-
Article
Evaluation of T2-FLAIR combined with ASL on the collateral circulation of acute ischemic stroke
Using magnetic resonance fluid-attenuated inversion recovery sequence (FLAIR) combined with three-dimensional arterial spin labeling (3D-ASL) cerebral perfusion imaging to explore the effect of collateral circ...
-
Article
Propofol Attenuates α-Synuclein Aggregation and Neuronal Damage in a Mouse Model of Ischemic Stroke
α-Synuclein is a soluble monomer abundant in the central nervous system. Aggregates of α-synuclein, consisting of higher-level oligomers and insoluble fibrils, have been observed in many chronic neurological d...
-
Article
Desflurane and Surgery Exposure During Pregnancy Decrease Synaptic Integrity and Induce Functional Deficits in Juvenile Offspring Mice
Anesthesia in pregnant women may cause adverse effects in the hippocampus of unborn babies and fetal brain development. The mechanisms underlying pathological changes resulting from anesthetics are unclear. Th...
-
Article
Open AccessVideo laryngoscopy does not improve the intubation outcomes in emergency and critical patients – a systematic review and meta-analysis of randomized controlled trials
There is significant controversy regarding the influence of video laryngoscopy on the intubation outcomes in emergency and critical patients. This systematic review and meta-analysis was designed to determine ...
-
Article
Open AccessChanges in duration of action of rocuronium following decrease in hepatic blood flow during pneumoperitoneum for laparoscopic gynaecological surgery
A moderate insufflation pressure and deep neuromuscular blockade (NMB) have been recommended in laparoscopic surgery in consideration of the possible reduction in splanchnic perfusion due to the CO2-pneumoperiton...
-
Article
Early Repeated Administration of CXCR4 Antagonist AMD3100 Dose-Dependently Improves Neuropathic Pain in Rats After L5 Spinal Nerve Ligation
AMD3100 is a specific C-X-C chemokine receptor type 4 (CXCR4) antagonist which blocks the interaction between CXCR4 and CXCL12. Multiple lines of evidence suggest that AMD3100 has analgesic effects on many pat...
-
Article
Internationalization for quality in Chinese research universities: student perspectives
China’s rapidly expanding university system aims to balance quantity and quality through a variety of measures, including internationalization. This paper employs data from a survey of 1264 students from 39 hi...
-
Article
Upregulation of α2δ−1 Calcium Channel Subunit in the Spinal Cord Contributes to Pelvic Organ Cross-Sensitization in a Rat Model of Experimentally-Induced Endometriosis
Pelvic organ cross-sensitization, also termed as viscero-visceral referred hyperalgesia, is a major contributor to painful endometriosis. Its underlying mechanism is poorly understood. Clinical and basic stud...
-
Article
Propofol-Induced Age-Different Hypocampal Long-Term Potentiation is Associated with F-Actin Polymerization in Rats
Elderly patients may experience a decline in cognition after a surgery performed under anesthesia. Propofol (2,6-diisopropylphenol), a common intravenous anesthetic agent, has been reported to mediate the long...
-
Article
Open AccessRocuronium blockade reversal with sugammadex vs. neostigmine: randomized study in Chinese and Caucasian subjects
This study compared efficacy and safety of the selective relaxant binding agent sugammadex (2 mg/kg) with neostigmine (50 μg/kg) for neuromuscular blockade (NMB) reversal in Chinese and Caucasian subjects.
-
Article
Profiling of the Soluble Proteome in Rat Hippocampus Post Propofol Anesthesia
The current study was designed to initially observe the changes in soluble proteome in rat hippocampus post anesthesia, trying to explore possible clues for elucidating the effects of propofol. Soluble protei...
-
Article
Can urinary excretion rate of 8-isoprostrane and malonaldehyde predict postoperative cognitive dysfunction in aging?
Oxidative stress has been associated with mild cognitive impairment (MCI) and Alzheimer’s disease (AD). However, little is known about oxidative stress in postoperative cognitive dysfunction (POCD) in aging. T...
-
Article
Hippocampal Glutamate Level and Glutamate Aspartate Transporter (GLAST) are Up-Regulated in Senior Rat Associated with Isoflurane-Induced Spatial Learning/Memory Impairment
Postoperative cognitive decline is a clinical concern especially for senior patients. It is generally recognized that glutamatergic system plays a crucial role in the physiopathologic process of neurocognitive...
-
Article
Aggravation Effect of Isoflurane on Aβ25–35-Induced Apoptosis and Tau Hyperphosphorylation in PC12 Cells
Some anesthetics have been suggested to induce Alzheimer’s disease (AD) neuro-pathogenesis. Increasing evidence indicates that hyperphosphorylated tau plays a key role in the pathogenic events that occur in AD...
-
Article
Postoperative Cognitive Dysfunction is Correlated with Urine Formaldehyde in Elderly Noncardiac Surgical Patients
Post-operative cognitive dysfunction (POCD), especially in elderly patients, has been reported in many studies. Although increasing age, duration of anesthesia, postoperative infections, and respiratory compli...
-
Article
Which is more effective in adolescent idiopathic scoliosis surgery: batroxobin, tranexamic acid or a combination?
Adolescent idiopathic scoliosis surgery is often associated with significant blood loss and blood transfusion. In this clinical trial, the authors investigated the efficacy of reducing blood loss and allogenei...
-
Article
Open AccessRNA interference-mediated silencing of BACE and APP attenuates the isoflurane-induced caspase activation
β-Amyloid protein (Aβ) has been shown to potentiate the caspase-3 activation induced by the commonly used inhalation anesthetic isoflurane. However, it is unknown whether reduction in Aβ levels can attenuate t...
-
Article
Synthesis and cytotoxicity of novel 3-amino-4-indolylmaleimide derivatives
In an attempt to develop potent and selective antitumor agents, a series of novel 3-amino-4-indolylmaleimides were designed and synthesized. The reaction showed high regioselectivity. The structure of compound 7a
