519 Result(s)
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Article
Yong-** Dong
Biomedicine
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Article
Open AccessHigh-does nitric oxide induces apoptosis in HL-60 human myeloid leukemia cells
The treatment of human promyeloid leukemia cell line HL-60 cells with nitric oxide (NO) is associated with loss of proliferative apacity and induction of monocytic differentiation. The present results demonstr...
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Mutations in the gene encoding gap junction protein β-3 associated with autosomal dominant hearing impairment
Hearing impairment is the most commonly occurring condition that affects the ability of humans to communicate 1 . More than 50%...
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Cloning and characterization of a novel cardiac-specific kinase that interacts specifically with cardiac troponin I
Cardiac-restricted genes play important roles in cardiovascular system. In an effort to identify such novel genes we identified a novel cardiac-specific kinase gene TNNI3K localized on 1p31.1 based on bioinformat...
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Effects of Dehydroevodiamine Exposure on Glutamate Release and Uptake in the Cultured Cerebellar Cells
Dehydroevodiamine has been reported to have neuroprotective and antiamnesic effects. This study examined the effects of dehydroevodiamine on glutamate release and uptake in cultured cerebellar cells. Chronic d...
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Expression of Expanded Polyglutamine Protein Induces Behavioral Changes in Drosophila (Polyglutamine-Induced Changes in Drosophila)
Spinocerebellar ataxia type-3 or Machado–Joseph disease (SCA3/MJD) is an autosomal dominant neurodegenerative disease caused by triplet nucleotide expansion. The expansion of the polyglutamine tract near the C...
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Polymorphisms of the prion protein gene (PRNP) in a Korean population
Human prion protein gene (PRNP) has been considered to be involved in the susceptibility of humans to prion diseases. Polymorphisms of methionine (Met)/valine (Val) at codon 129 and of glutamic acid (Glu)/lysi...
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Open AccessActivated natural killer cell-mediated immunity is required for the inhibition of tumor metastasis by dendritic cell vaccination
Immunization with dendritic cells (DCs) pulsed with tumor antigen can activate tumor-specific cytotoxic T lymphocytes (CTL), which is responsible for tumor protection and regression. In this study, we examined...
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Open AccessIncreased lysine N-methylation of a 23-kDa protein during hepatic regeneration
The methylation of a 23-kDa nuclear protein increased after partial hepatectomy and methylation returned to basal levels after the initial stage of regeneration. The methylating enzyme was partially purified f...
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Open AccessMethyl gallate and chemicals structurally related to methyl gallate protect human umbilical vein endothelial cells from oxidative stress
Methyl gallate (meGAL) is known as one of major antioxidants. To investigate whether meGAL protects human cells from oxidative stress, meGAL extracted from Korean medicinal plant, Cercis chinensis leaves, was pri...
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Open AccessNatural compounds, fraxin and chemicals structurally related to fraxin protect cells from oxidative stress
Coumarins comprise a group of natural phenolic compounds found in a variety of plant sources. In view of the established low toxicity, relative cheapness, presence in the diet and occurrence in various herbal ...
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Genetic linkage of human height is confirmed to 9q22 and Xq24
Human height is an important and heritable trait. Our previous two genome-wide linkage studies using 630 (WG1 study) and an extended sample of 1,816 Caucasians (WG2 study) identified 9q22 [maximum LOD score (M...
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Characteristics of Ca2+-exocytosis coupling in isolated mouse pancreatic β cells
To characterize Ca2+-stimulated exocytosis in isolated mouse pancreatic β cells.
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Neutral sulfate berberine modulates cytokine secretion and increases survival in endotoxemic mice
Berberine is thought to be an immunomodulator, so the present study aimed to investigate the effect of berberine on mortality, lung and intestine injury in endotoxemic mice, and the mechanism of its action.
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Chronological Distribution of Rip Immunoreactivity in the Gerbil Hippocampus During Normal Aging
Age-dependent studies on oligodendrocytes, which are the myelinating cells in the central nervous system, have been relatively less investigated. We examined age-dependent changes in Rip immunoreactivity and i...
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Glucosamine sulfate–induced apoptosis in chronic myelogenous leukemia K562 cells is associated with translocation of cathepsin D and downregulation of Bcl-xL
Cathepsin D (cat D) reportedly plays an important role in certain apoptotic processes, the downstream pathways of which involve release of cytochrome c (cyt c) from mitochondria and activation of the caspase casc...
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Granulocyte-macrophage colony-stimulating factor DNA prime-protein boost strategy to enhance efficacy of a recombinant pertussis DNA vaccine
To investigate a new strategy to enhance the efficacy of a recombinant pertussis DNA vaccine. The strategy is co-injection with cytokine plasmids as prime, and boosted with purified homologous proteins.
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Caveolin-1 is important for nitric oxide-mediated angiogenesis in fibrin gels with human umbilical vein endothelial cells
The role of caveolin-1 (Cav-1) in angiogenesis remains poorly understood. The endothelial nitric oxide (NO) synthase (eNOS), a caveolin-interacting protein, was demonstrated to play a predominant role in vascu...
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Open AccessTissue microarray analysis reveals a tight correlation between protein expression pattern and progression of esophageal squamous cell carcinoma
The development of esophageal squamous cell carcinoma (ESCC) progresses a multistage process, collectively known as precursor lesions, also called dysplasia (DYS) and carcinoma in situ (CIS), subsequent invasive ...
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Identification of Leukemia-Specific Fusion Gene Transcripts with a Novel Oligonucleotide Array
Background: Identification of specific chromosomal translocations is essential for the diagnosis and prognosis of leukemia. In this study, we employ DNA microarray technology to detect chromosoma...
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Urotensin II accelerates cardiac fibrosis and hypertrophy of rats induced by isoproterenol
To study whether urotensin II (UII), a potent vasoconstrictive peptide, is involved in the development of cardiac hypertrophy and fibrogenesis of rats induced by isoproterenol (ISO).
