35 Result(s)

Article

Identification of metabolites with anticancer properties by computational metabolomics

Certain endogenous metabolites can influence the rate of cancer cell growth. For example, diacylglycerol, ceramides and sphingosine, NAD⁺ and arginine exert this effect by acting as signaling molecules, while car...

Adrian K Arakaki, Roman Mezencev, Nathan J Bowen, Ying Huang… in Molecular Cancer (2008)

Article

Inhibitory effect of ginsenoside Rg3 combined with gemcitabine on angiogenesis and growth of lung cancer in mice

Ginsenoside Rg3, a saponin extracted from ginseng, inhibits angiogenesis. The combination of low-dose chemotherapy and anti-angiogenic inhibitors suppresses growth of experimental tumors more effectively than ...

Tai-Guo Liu, Ying Huang, Dan-Dan Cui, **ao-Bing Huang, Shu-Hua Mao… in BMC Cancer (2009)

Article

RRM1 single nucleotide polymorphism -37C→A correlates with progression-free survival in NSCLC patients after gemcitabine-based chemotherapy

The ribonucleotide reductase M1 (RRM1) gene encodes the regulatory subunit of ribonucleotide reductase, the molecular target of gemcitabine. The overexpression of RRM1 mRNA in tumor tissues is reported to be a...

Song Dong, Ai-Lin Guo, Zhi-Hong Chen, Zhen Wang… in Journal of Hematology & Oncology (2010)

Article

The alkylphospholipid, perifosine, radiosensitizes prostate cancer cells both in vitro and in vivo

Perifosine is a membrane-targeted alkylphospholipid developed to inhibit the PI3K/Akt pathway and has been suggested as a favorable candidate for combined use with radiotherapy. In this study, we investigated ...

Yuanhong Gao, Hiromichi Ishiyama, Mianen Sun, Kathryn L Brinkman… in Radiation Oncology (2011)

Article

Inhibitory effect of Bifidobacterium infantis-mediated sKDR prokaryotic expression system on angiogenesis and growth of Lewis lung cancer in mice

To construct the Bifidobacterium infantis-mediated soluble kinase insert domain receptor (sKDR) prokaryotic expression system and to observe its inhibitory effect on growth of human umbilicus vessel endothelial c...

Zhao-Jun Li, Hong Zhu, Bu-Yun Ma, Fen Zhao, Shu-Hua Mao, Tai-Guo Liu… in BMC Cancer (2012)

Article

Analysis of dosimetric factors associated with temporal lobe necrosis (TLN) in patients with nasopharyngeal carcinoma (NPC) after intensity modulated radiotherapy

The radiation tolerance dose-volume in brain remains unclear for nasopharyngeal carcinoma (NPC) patients treated with intensity modulated radiotherapy (IMRT). We performed this study to investigate dosimetric ...

Sheng-Fa Su, Shao-Ming Huang, Fei Han, Ying Huang, Chun-Yan Chen… in Radiation Oncology (2013)

Article

A comparative dosimetric study for treating left-sided breast cancer for small breast size using five different radiotherapy techniques: conventional tangential field, filed-in-filed, Tangential-IMRT, Multi-beam IMRT and VMAT

To compare the dosimetry for the left-sided breast cancer treatment using five different radiotherapy techniques.

Guang-Hua **, Li-**n Chen, **ao-Wu Deng, **ao-Wei Liu, Ying Huang… in Radiation Oncology (2013)

Article

Comparing treatment outcomes of different chemotherapy sequences during intensity modulated radiotherapy for advanced N-stage nasopharyngeal carcinoma patients

N-stage is related to distant metastasis of nasopharyngeal carcinoma (NPC) patients. We performed this study to compare the efficacy of different chemotherapy sequences in advanced N-stage (N2 and N3) NPC pati...

Xueming Sun, Lei Zeng, Chunyan Chen, Ying Huang, Fei Han, Weiwei **ao… in Radiation Oncology (2013)

Article

SOX1 down-regulates β-catenin and reverses malignant phenotype in nasopharyngeal carcinoma

Aberrant activation of the Wnt/β-catenin signaling pathway is an important factor in the development of nasopharyngeal carcinoma (NPC). Previous studies have demonstrated that the developmental gene sex-determ...

Zhong Guan, Jialiang Zhang, **g Wang, Hefei Wang, Feimeng Zheng… in Molecular Cancer (2014)

Article

Evaluation of transabdominal ultrasound after oral administration of an echoic cellulose-based gastric ultrasound contrast agent for gastric cancer

With the remarkable improvements in ultrasound equipment, transabdominal ultrasound after oral administration of an echoic cellulose-based gastric ultrasound contrast agent (TUS-OCCA) has recently been suggest...

Zhijun Liu, **tao Guo, Shupeng Wang, Ying Zhao, **g Li, Weidong Ren… in BMC Cancer (2015)

Article

AKT1^low quiescent cancer cells persist after neoadjuvant chemotherapy in triple negative breast cancer

Absence of pathologic complete response (pCR) to neoadjuvant chemotherapy (NACT) correlates with poor long-term survival in patients with triple negative breast cancer (TNBC). These incomplete treatment respon...

Sheheryar Kabraji, Xavier Solé, Ying Huang, Clyde Bango… in Breast Cancer Research (2017)

Article

Phase II randomized, double-blind, placebo-controlled study of tivantinib in men with asymptomatic or minimally symptomatic metastatic castration-resistant prostate cancer (mCRPC)

Background Tivantinib is a non-ATP competitive inhibitor of c-MET receptor tyrosine kinase that may have additional cytotoxic mechanisms including tubulin inhibition. Prostate cancer demonstrates higher c-MET exp...

Paul Monk, Glenn Liu, Walter M. Stadler, Susan Geyer… in Investigational New Drugs (2018)

Article

AKT1^low quiescent cancer cells in ductal carcinoma in situ of the breast

Ductal carcinoma in situ (DCIS) of the breast precedes the development of invasive breast cancer and reflects the genomic changes and protein expression profile of invasive disease. AKT1^low cancer cells (QCC) are...

Sheheryar Kabraji, Xaiver Sole, Ying Huang, Clyde Bango, Dennis Sgroi… in npj Breast Cancer (2019)

Article

CHTM1 regulates cancer cell sensitivity to metabolic stress via p38-AIF1 pathway

Recently, we have reported the characterization of a novel protein named Coiled-coil Helix Tumor and Metabolism 1 (CHTM1). CHTM1 localizes to both cytosol and mitochondria. Sequence corresponding to CHTM1 is a...

Mansi Babbar, Ying Huang… in Journal of Experimental & Clinical Cancer … (2019)

Article

Downregulated SPINK4 is associated with poor survival in colorectal cancer

SPINK4 is known as a gastrointestinal peptide in the gastrointestinal tract and is abundantly expressed in human goblet cells. The clinical significance of SPINK4 in colorectal cancer (CRC) is largely unknown.

**aojie Wang, Qian Yu, Waleed M. Ghareeb, Yiyi Zhang, **ngrong Lu, Ying Huang… in BMC Cancer (2019)

Article

Tissue mechanics and expression of TROP2 in oral squamous cell carcinoma with varying differentiation

Trophoblast cell surface antigen 2 (TROP2) is overexpressed in many squamous cell carcinomas and promotes tumor development and invasion. The association between TROP2 expression and occurrence and development...

Bao** Zhang, Shuting Gao, Rui** Li, Yiting Li, Rui Cao, **gyang Cheng… in BMC Cancer (2020)

Article

Regression models for predicting physical and EQD₂ plan parameters of two methods of hybrid planning for stage III NSCLC

To establish regression models of physical and equivalent dose in 2 Gy per fraction (EQD₂) plan parameters of two kinds of hybrid planning for stage III NSCLC.

Hao Wang, Yongkang Zhou, Wutian Gan, Hua Chen, Ying Huang… in Radiation Oncology (2021)

Article

FAM122A is required for hematopoietic stem cell function

Man-Hua Liu, **ao-Cui Zhang, **g Chen, Yun-Sheng Yang, Yin-Qi Wang… in Leukemia (2021)

Article

Dosimetric comparison and biological evaluation of fixed-jaw intensity-modulated radiation therapy for T-shaped esophageal cancer

To evaluate the dosimetric and biological benefits of the fixed-jaw (FJ) intensity-modulated radiation therapy (IMRT) technique for patients with T-shaped esophageal cancer.

Hua Chen, Ying Huang, Hao Wang, Yan Shao, Ning J. Yue, Hengle Gu… in Radiation Oncology (2021)

Article

Safety and efficacy of thalidomide in patients with transfusion-dependent β-thalassemia: a randomized clinical trial

Thalidomide induces γ-globin expression in erythroid progenitor cells, but its efficacy on patients with transfusion-dependent β-thalassemia (TDT) remains unclear. In this phase 2, multi-center, randomized, do...

Jiang-Ming Chen, Wei-Jian Zhu, Jie Liu… in Signal Transduction and Targeted Therapy (2021)