34 Result(s)

Article

p27^Kip1 overexpression causes apoptotic death of mammalian cells

p27^Kip1, a member of the Cip/Kip family of cyclin-dependent kinase (cdk) inhibitors, has been implicated in mediating G1 arrest in response to a variety of growth inhibitory signals. Its importance in regulating ...

**antao Wang, Myriam Gorospe, Ying Huang, Nikki J Holbrook in Oncogene (1997)

Article

Ultraviolet-irradiation-induced apoptosis is mediated via ligand independent activation of tumor necrosis factor receptor 1

Ultraviolet (UV)-irradiation has been shown to induce jun N-terminal kinase activity via aggregation-mediated activation of tumor necrosis factor receptor 1 (TNFR1) but the role of TNFR1 in mediating UV-induced a...

M Saeed Sheikh, Michael J Antinore, Ying Huang, Albert J Fornace Jr in Oncogene (1998)

Article

Serine protease inhibitor TPCK prevents Taxol-induced cell death and blocks c-Raf-1 and Bcl-2 phosphorylation in human breast carcinoma cells

The mechanism of Taxol-induced apoptosis was investigated in MCF-7 human breast carcinoma cells. Taxol-induced apoptosis was associated with phosphorylation of both c-Raf-1 and Bcl-2 and activation of ERK and ...

Ying Huang, M Saeed Sheikh, Albert J Fornace Jr, Nikki J Holbrook in Oncogene (1999)

Article

The antiapoptotic decoy receptor TRID/TRAIL-R3 is a p53-regulated DNA damage-inducible gene that is overexpressed in primary tumors of the gastrointestinal tract

Both DR4 and DR5 have recently been identified as membrane death receptors that are activated by their ligand TRAIL to engage the intracellular apoptotic machinery. TRID (also named as TRAIL-R3) is an antagoni...

M Saeed Sheikh, Ying Huang, Ester A Fernandez-Salas, Wafik S El-Deiry… in Oncogene (1999)

Article

TC21 mediates transformation and cell survival via activation of phosphatidylinositol 3-kinase/Akt and NF-κB signaling pathway

The signaling pathways of TC21-mediated transformation and cell survival are not well-established. In this study, we have investigated the role of PI3-K/Akt signaling pathway in oncogenic-TC21-mediated transfo...

Rong Rong, Qin He, Yusen Liu, M Saeed Sheikh, Ying Huang in Oncogene (2002)

Article

Endoplasmic reticulum calcium pool depletion-induced apoptosis is coupled with activation of the death receptor 5 pathway

Thapsigargin (TG), by inducing perturbations in cellular Ca²⁺ homeostasis, has been shown to induce apoptosis. The molecular mechanisms of Ca²⁺ perturbation-induced apoptosis are not fully understood. In this stu...

Qin He, Dong Ik Lee, Rong Rong, Myounghee Yu, **uquan Luo, Michael Klein… in Oncogene (2002)

Article

Apo2L/TRAIL differentially modulates the apoptotic effects of sulindac and a COX-2 selective non-steroidal anti-inflammatory agent in Bax-deficient cells

The nonsteroidal anti-inflammatory drugs (NSAIDs) are believed to mediate their anticancer effects by inducing apoptosis but the molecular mechanisms of their apoptotic effects remain largely unknown. Here we ...

Qin He, **uquan Luo, Ying Huang, M Saeed Sheikh in Oncogene (2002)

Article

Effect of Bax deficiency on death receptor 5 and mitochondrial pathways during endoplasmic reticulum calcium pool depletion-induced apoptosis

Thapsigargin (TG), by inducing perturbations in cellular Ca²⁺ homeostasis, can induce apoptosis, but the molecular mechanisms remain to be fully elucidated. We have recently reported that TG-induced apoptosis app...

Qin He, JoAnne Montalbano, Chad Corcoran, Weixin **, Ying Huang… in Oncogene (2003)

Article

Cloning and characterization of a novel gene PDRG that is differentially regulated by p53 and ultraviolet radiation

We report the cloning and characterization of a novel p53 and DNA damage-regulated gene (PDRG). The human and mouse PDRG sequences are highly homologous and contain open reading frames of 133 amino acids each ...

**uquan Luo, Ying Huang, M Saeed Sheikh in Oncogene (2003)

Article

Bax deficiency affects caspase-2 activation during ultraviolet radiation-induced apoptosis

There has been a considerable debate as to whether caspase-2 is an initiator or effector caspase. Recently, a new model of intrinsic pathway of apoptosis has been proposed, which suggests caspase-2 to be an in...

Qin He, Ying Huang, M Saeed Sheikh in Oncogene (2004)

Article

Apoptosis signaling by the novel compound 3-Cl-AHPC involves increased EGFR proteolysis and accompanying decreased phosphatidylinositol 3-kinase and AKT kinase activities

The threonine and serine protein kinase AKT plays a major role in inhibiting apoptosis in a number of malignant cell types including prostate and breast carcinoma. Activation of AKT is a complex process involv...

Lulu Farhana, Marcia I Dawson, Ying Huang, Yuxiang Zhang, Arun K Rishi… in Oncogene (2004)

Article

Proteasome inhibitor MG132 upregulates death receptor 5 and cooperates with Apo2L/TRAIL to induce apoptosis in Bax-proficient and -deficient cells

Apo2L/TRAIL (tumor necrosis factor-related apoptosis inducing ligand (TRAIL), also known as Apo2L) is a potentially important anticancer agent awaiting clinical trials. Unfortunately, however, some cancer cell...

Qin He, Ying Huang, M Saeed Sheikh in Oncogene (2004)

Article

Tumor suppressor RASSF1A is a microtubule-binding protein that stabilizes microtubules and induces G₂/M arrest

RASSF1A is a putative tumor suppressor gene that is inactivated in a variety of human tumors. Expression of exogenous RASSF1A has been shown to inhibit tumor growth in vitro and in animals. However, the molecular...

Rong Rong, Weixin **, Jennifer Zhang, M Saeed Sheikh, Ying Huang in Oncogene (2004)

Article

Cyclooxygenase-2 interacts with p53 and interferes with p53-dependent transcription and apoptosis

Cyclooxygenase-2 (COX-2) has been implicated in a variety of human malignancies and, accordingly, COX-2 selective inhibitors are being investigated as important chemopreventive and therapeutic agents. How COX-...

Chad A Corcoran, Qin He, Ying Huang, M Saeed Sheikh in Oncogene (2005)

Article

Oncogenic Ras-mediated downregulation of Gadd153/CHOP is required for Ras-induced cellular transformation

Oncogenic Ras proteins transform cells via multiple downstream signaling cascades that are important for cell proliferation and survival. Gadd153, also known as CHOP, is a growth inhibitory and proapoptotic pr...

Rong Rong, JoAnne Montalbano, Weixin **, Jennifer Zhang, Maria Garling… in Oncogene (2005)

Article

CHTM1, a novel metabolic marker deregulated in human malignancies

A better understanding of the link between cellular metabolism and tumorigenesis is needed. Here, we report characterization of a novel protein named coiled-coil helix tumor and metabolism 1 (CHTM1). We have f...

Mansi Babbar, Ying Huang, Jie An, Steve K. Landas, M. Saeed Sheikh in Oncogene (2018)

Article

Ninety-minute daratumumab infusion is safe in multiple myeloma

Hallie Barr, Jessica Dempsey, Allyson Waller, Ying Huang, Nita Williams… in Leukemia (2018)