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  1. No Access

    Article

    Targeting the chromatin binding of exportin-1 disrupts NFAT and T cell activation

    Exportin-1 (XPO1/CRM1) plays a central role in the nuclear-to-cytoplasmic transport of hundreds of proteins and contributes to other cellular processes, such as centrosome duplication. Small molecules targetin...

    Yi Fan Chen, Maryam Ghazala, Ryan M. Friedrich… in Nature Chemical Biology (2024)

  2. Article

    Open Access

    Ribonucleotide reductase M2B in the myofibers modulates stem cell fate in skeletal muscle

    The balance among quiescence, differentiation, and self-renewal of skeletal muscle stem cells (MuSCs) is tightly regulated by their intrinsic and extrinsic properties from the niche. How the niche controls MuS...

    Wan-**g Chen, I-Hsuan Lin, Chien-Wei Lee, Kiyoshi Yoshioka… in npj Regenerative Medicine (2022)

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  3. Article

    Open Access

    The therapeutic effect of the BRD4-degrading PROTAC A1874 in human colon cancer cells

    A1874 is a novel BRD4-degrading proteolysis targeting chimera (PROTAC). In primary colon cancer cells and established HCT116 cells, A1874 potently inhibited cell viability, proliferation, cell cycle progressio...

    An-cheng Qin, Hua **, Yu Song, Yun Gao, Yi-Fan Chen, Li-na Zhou… in Cell Death & Disease (2020)

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  4. No Access

    Article

    Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases

    Protein–protein interactions between E3 ubiquitin ligases and protein termini help shape the proteome. These interactions are sensitive to proteolysis, which alters the ensemble of cellular N and C termini. He...

    Matthew Ravalin, Panagiotis Theofilas, Koli Basu… in Nature Chemical Biology (2019)