6 Result(s)

Article

Immunization with cytomegalovirus envelope glycoprotein M and glycoprotein N DNA vaccines can provide mice with complete protection against a lethal murine cytomegalovirus challenge

Human cytomegalovirus virions contain three major glycoprotein complexes (gC I, II, III), all of which are required for CMV infectivity. These complexes also represent major antigenic targets for anti-viral im...

Huadong Wang, Yanfeng Yao, Chaoyang Huang, Quanjiao Chen, Jianjun Chen… in Virologica Sinica (2013)

Article

Evaluation of neutralizing efficacy of monoclonal antibodies specific for 2009 pandemic H1N1 influenza A virus in vitro and in vivo

Pandemic influenza A virus (H1N1) 2009 poses a serious public-health challenge worldwide. To characterize the neutralizing epitopes of this virus, we generated a panel of eight monoclonal antibodies (mAbs) aga...

Jianjun Chen, Bin Yan, Quanjiao Chen, Yanfeng Yao, Huadong Wang… in Archives of Virology (2014)

Article

Comparative analysis of antibody induction and protection against influenza virus infection by DNA immunization with HA, HAe, and HA1 in mice

Plasmid DNA vaccines are considered alternatives to inactivated influenza virus vaccines to control influenza. Vaccination with a hemagglutinin (HA)-, HA ectodomain (HAe)-, or HA subunit 1 (HA1)-based vaccine...

Jianjun Chen, Qian Liu, Quanjiao Chen, Chaochao **ong, Yanfeng Yao… in Archives of Virology (2014)

Article

MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2

Middle East respiratory syndrome coronavirus (MERS-CoV) causes sporadic zoonotic disease and healthcare-associated outbreaks in human. MERS is often complicated by acute respiratory distress syndrome (ARDS) an...

Man-Lung Yeung, Yanfeng Yao, Lilong Jia, Jasper F. W. Chan… in Nature Microbiology (2016)

Article

Avian Influenza A (H7N9) Virus in a Wild Land Bird in Central China, Late 2015

Yanfeng Yao, Tao Zhang, Wenhai Yang, Zhiyong Shao, Bin He… in Virologica Sinica (2018)

Article

Both chimpanzee adenovirus-vectored and DNA vaccines induced long-term immunity against Nipah virus infection

Nipah virus (NiV) is a highly lethal zoonotic paramyxovirus that poses a severe threat to humans due to its high morbidity and the lack of viable countermeasures. Vaccines are the most crucial defense against ...

Mingqing Lu, Yanfeng Yao, Xuekai Zhang, Hang Liu, Ge Gao, Yun Peng… in npj Vaccines (2023)