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  1. Article

    Open Access

    The effect of a germline mutation in the APC gene on β-catenin in human embryonic stem cells

    Most cases of colorectal cancer (CRC) are initiated by inactivation mutations in the APC gene, which is a negative regulator of the Wnt-β-catenin pathway. Patients with familial adenomatous polyposis (FAP) inh...

    Nofar Yedid, Yael Kalma, Mira Malcov, Ami Amit, Revital Kariv, Michal Caspi… in BMC Cancer (2016)

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    Article

    E2Fs up-regulate expression of genes involved in DNA replication, DNA repair and mitosis

    The E2F family of transcription factors plays a pivotal role in the regulation of cell proliferation in higher eukaryotes. We used DNA microarrays and cell lines containing either inducible E2F-1 or inducible ...

    Shirley Polager, Yael Kalma, Eli Berkovich, Doron Ginsberg in Oncogene (2002)

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    Article

    Expression analysis using DNA microarrays demonstrates that E2F-1 up-regulates expression of DNA replication genes including replication protein A2

    The transcription factor E2F-1 plays a pivotal role in the regulation of G1/S transition in higher eukaryotes cell cycle. We used a cell line containing an inducible E2F-1 and oligonucleotide microarray analys...

    Yael Kalma, Lea Marash, Yocheved Lamed, Doron Ginsberg in Oncogene (2001)