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  1. Article

    Open Access

    Hydroxydibenzoylmethane induces apoptosis through repressing ornithine decarboxylase in human promyelocytic leukemia HL-60 cells

    Ornithine decarboxylase (ODC) is the rate-limiting enzyme in polyamine biosynthesis and a target for chemoprevention. Hydroxydibenzoylmethane (HDB), a derivative of dibenzoylmethane of licorice, is a promising...

    Ming-Fu Wang, Ya-Fan Liao, Ying-Cheng Hung… in Experimental & Molecular Medicine (2011)

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    Article

    Overexpression of ornithine decarboxylase suppresses thapsigargin-induced apoptosis

    Ornithine decarboxylase (ODC), the key enzyme of polyamine biosynthesis, has paradoxical roles in apoptosis. Our published papers show overexpression of ODC prevents the apoptosis induced by many cytotoxic dru...

    Wei-Chung Hsieh, Pei-Chen Hsu, Ya-Fan Liao, Shu-Ting Young… in Molecules and Cells (2010)

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    Article

    The functional haplotype of peptidylarginine deiminase IV (S55G, A82V and A112G) associated with susceptibility to rheumatoid arthritis dominates apoptosis of acute T leukemia Jurkat cells

    Peptidylarginine deiminase IV (PADI4) posttranslationally converts peptidylarginine to citrulline. It plays an essential role in immune cell differentiation and apoptosis. A haplotype of single-nucleotide poly...

    Hui-Chih Hung, Chien-Yu Lin, Ya-Fan Liao, Pei-Chen Hsu, Gregory J. Tsay… in Apoptosis (2007)