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  1. Article

    Tolerability, pharmacokinetics and pharmacodynamics of CMAB001, an anti-CD11a antibody, in Chinese healthy volunteers and psoriatic patients

    To evaluate the pharmacokinetics (PK), pharmacodynamics (PD) and primary tolerability of an anti-CD11a monoclonal antibody (CMAB001) in Chinese healthy volunteers and psoriatic patients.

    ** Li, **g Li, Heng Yan, Bo Zhou, Bo-hua Li in Acta Pharmacologica Sinica (2012)

  2. Article

    The dual role of osteopontin in acetaminophen hepatotoxicity

    Osteopontin (OPN), a multifunctional protein, has been reported to be protoxicant in acetaminophen hepatotoxicity. In this study, the mechanisms underlying the detrimental role of OPN in acetaminophen toxicity...

    Chun-yan He, Bei-bei Liang, **ao-yu Fan, Lei Cao, Rui Chen in Acta Pharmacologica Sinica (2012)

  3. Article

    Pharmacokinetics of CTLA4Ig fusion protein in healthy volunteers and patients with rheumatoid arthritis

    To evaluate single-dose and multiple-dose pharmacokinetics of cytotoxic T-lymphocyte-associated antigen 4 fusion protein (CTLA4Ig) in healthy volunteers and patients with rheumatoid arthritis (RA).

    Ying Ma, Bi-rong Lin, Bei Lin, Sheng Hou, Wei-zhu Qian in Acta Pharmacologica Sinica (2009)

  4. Article

    Pharmacokinetic and pharmacodynamic study of LFA3Ig fusion protein in healthy volunteers and patients with psoriasis

    To evaluate the pharmacokinetics (PK) and pharmacodynamics of the LFA3Ig fusion protein (LFA3IgFP) in healthy volunteers and patients with chronic plaque psoriasis.

    ** Li, **g Li, Heng Yan, Sheng Hou, Wei-zhu Qian in Acta Pharmacologica Sinica (2008)