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  1. Article

    Open Access

    Phase 1 study of oral selective estrogen receptor degrader (SERD) amcenestrant (SAR439859), in Japanese women with ER-positive and HER2-negative advanced breast cancer (AMEERA-2)

    This AMEERA-2 study evaluated the pharmacokinetics, efficacy, and safety of the oral selective estrogen receptor degrader amcenestrant as a monotherapy with dose escalation in Japanese postmenopausal women wit...

    Kenji Tamura, Toru Mukohara, Kan Yonemori, Yumiko Kawabata, Xavier Nicolas… in Breast Cancer (2023)

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  2. Article

    Interaction of a droplet spray with a turbulent plane air jet impacting a wall

    Experiments are carried out to study the interaction of a spray of spherical micronic oil droplets with a turbulent plane air jet impacting a wall. The context is the separation of a contaminated atmosphere wi...

    Syphax Ikardouchene, Stéphane Delaby, Xavier Nicolas in Experiments in Fluids (2023)

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  3. Article

    Open Access

    Population Pharmacokinetic/Pharmacodynamic Analysis of Alirocumab in Healthy Volunteers or Hypercholesterolemic Subjects Using an Indirect Response Model to Predict Low-Density Lipoprotein Cholesterol Lowering: Support for a Biologics License Application Submission: Part II

    Alirocumab, a human monoclonal antibody against proprotein convertase subtilisin/kexin type 9 (PCSK9), significantly lowers low-density lipoprotein cholesterol levels.

    Xavier Nicolas, Nassim Djebli, Clémence Rauch, Aurélie Brunet… in Clinical Pharmacokinetics (2019)

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  4. No Access

    Article

    Boiling in Porous Media: Model and Simulations

    We present a modelization of the heat and mass transfers within a porous medium, which takes into account phase transitions. Classical equations are derived for the mass conservation equation, whereas the equa...

    Johann Bénard, Robert Eymard, Xavier Nicolas, Clément Chavant in Transport in Porous Media (2005)