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  1. No Access

    Article

    Tannic Acid Impedes the Proliferation of Bladder Cancer Cells by Elevating Mitochondrial Pathways of Apoptosis

    Bladder cancer stands as a prevailing neoplasm among men globally, distinguished for its pronounced malignancy attributed to invasiveness and metastatic proclivity. Tannic acid (TA), an organic compound in man...

    Chi-Cheng Li, Bruce Chi-Kang Tsai… in Cell Biochemistry and Biophysics (2024)

  2. Article

    Open Access

    CircMAST1 inhibits cervical cancer progression by hindering the N4-acetylcytidine modification of YAP mRNA

    Cervical cancer (CCa) is the fourth most common cancer among females, with high incidence and mortality rates. Circular RNAs (circRNAs) are key regulators of various biological processes in cancer. However, th...

    Chunyu Zhang, Li Yuan, Qiaojian Zou, Caixia Shao… in Cellular & Molecular Biology Letters (2024)

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  3. Article

    Open Access

    The dual antimicrobial and immunomodulatory roles of host defense peptides and their applications in animal production

    Host defense peptides (HDPs) are small molecules with broad-spectrum antimicrobial activities against infectious bacteria, viruses, and fungi. Increasing evidence suggests that HDPs can also indirectly protect...

    Di Wu, Linglong Fu, Weizhang Wen, Na Dong in Journal of Animal Science and Biotechnology (2022)

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  4. No Access

    Article

    Extracellular production of Ulp1403-621 in leaky E. coli and its application in antimicrobial peptide production

    Small ubiquitin-like modifier (SUMO) tag is widely used to promote soluble expression of exogenous proteins, which can then be cleaved by ubiquitin-like protease 1 (Ulp1) to obtain interested protein. But the ...

    Linglong Fu, Mengning Sun, Weizhang Wen, Na Dong… in Applied Microbiology and Biotechnology (2022)

  5. Article

    Open Access

    HIF-1α/JMJD1A signaling regulates inflammation and oxidative stress following hyperglycemia and hypoxia-induced vascular cell injury

    Endothelial cell (EC) injury accelerates the progression of diabetic macrovascular complications. Hypoxia is an important cause of EC injury. Hypoxia-inducible factor-1 alpha (HIF-1α) is an important hypoxia r...

    Min Zhao, Shaoting Wang, Anna Zuo, Jiaxing Zhang… in Cellular & Molecular Biology Letters (2021)

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  6. No Access

    Article

    Genome-wide linkage map** for canopy activity related traits using three RIL populations in bread wheat

    Among yield contributing traits, the contribution of canopy activity related traits has been less studied. In this study, quantitative trait loci (QTL) for the normalized difference vegetation index (NDVI) at ...

    Faji Li, Weie Wen, **dong Liu, Shengnan Zhai, **nyou Cao, Cheng Liu… in Euphytica (2021)

  7. No Access

    Article

    The Function and Mechanism of Enterovirus 71 (EV71) 3C Protease

    Enterovirus 71 (EV71) is the main pathogen of the hand, foot, and mouth disease. It was firstly isolated from sputum specimens of infants with central nervous system diseases in California in 1969, and has been r...

    Weihui Wen, Zixuan Qi, **g Wang in Current Microbiology (2020)

  8. No Access

    Article

    Development and validation of high-throughput and low-cost STARP assays for genes underpinning economically important traits in wheat

    We developed and validated 56 gene-specific semi-thermal asymmetric reverse PCR (STARP) markers for 46 genes of important wheat quality, biotic and abiotic stress resistance, grain yield, and adaptation-relate...

    Yuying Wu, Ming Li, Zhonghu He, Susanne Dreisigacker… in Theoretical and Applied Genetics (2020)

  9. No Access

    Article

    Production and excretion of astaxanthin by engineered Yarrowia lipolytica using plant oil as both the carbon source and the biocompatible extractant

    This study aimed to develop a bioprocess using plant oil as the carbon source for lipid-assimilating yeast to produce high-value astaxanthin. Using high-oleic safflower oil as a model, efficient cell growth an...

    Ningyang Li, Zhenlin Han, Timothy J. O’Donnell… in Applied Microbiology and Biotechnology (2020)

  10. No Access

    Article

    Genetic dissection of a major QTL for kernel weight spanning the Rht-B1 locus in bread wheat

    Genetic dissection uncovered a major QTL QTKW.caas-4BS corresponding with a 483 kb deletion that included genes ZnF, EamA and Rht-B1. This deletion was associated with increased grain weight and semi-dwarf phenot...

    Dengan Xu, Weie Wen, Lu** Fu, Faji Li, Jihu Li… in Theoretical and Applied Genetics (2019)

  11. No Access

    Article

    Genome-wide variation patterns between landraces and cultivars uncover divergent selection during modern wheat breeding

    Genetic diversity, population structure, LD decay, and selective sweeps in 687 wheat accessions were analyzed, providing relevant guidelines to facilitate the use of the germplasm in wheat breeding.

    **dong Liu, Awais Rasheed, Zhonghu He, Muhammad Imtiaz… in Theoretical and Applied Genetics (2019)

  12. No Access

    Article

    Genome-wide linkage map** of yield-related traits in three Chinese bread wheat populations using high-density SNP markers

    We identified 21 new and stable QTL, and 11 QTL clusters for yield-related traits in three bread wheat populations using the wheat 90 K SNP assay.

    Faji Li, Weie Wen, Zhonghu He, **dong Liu, Hui **… in Theoretical and Applied Genetics (2018)

  13. No Access

    Article

    Intein-mediated assembly of tunable scaffoldins for facile synthesis of designer cellulosomes

    In this study, extended artificial scaffoldins possessing multiple cohesin modules were created in vivo by employing split-intein-mediated protein ligation. Artificial scaffoldins having one Clostridium thermocel...

    Zhenlin Han, Wei Wen Su in Applied Microbiology and Biotechnology (2018)

  14. No Access

    Article

    Cloning of TaTPP-6AL1 associated with grain weight in bread wheat and development of functional marker

    Trehalose 6-phosphate phosphatase (TPP) dephosphorylates trehalose 6-phosphate to trehalose, an important growth regulator, and is involved in starch accumulation and grain yield. In this study, wheat TPP homolog...

    Pengfei Zhang, Zhonghu He, **uling Tian, Fengmei Gao, Dengan Xu… in Molecular Breeding (2017)

  15. No Access

    Article

    TaELF3-1DL, a homolog of ELF3, is associated with heading date in bread wheat

    Early flowering 3 (ELF3) is a regulator to modulate photoperiod flowering in Arabidopsis. The homologs of ELF3 in rice and barley also have been identified essential for regulation of flowering time. In the curre...

    **** Wang, Weie Wen, Mamoona Hanif, **anchun **a, Honggang Wang… in Molecular Breeding (2016)

  16. No Access

    Article

    Genome-wide linkage map** of QTL for black point reaction in bread wheat (Triticum aestivum L.)

    Nine QTL for black point resistance in wheat were identified using a RIL population derived from a Linmai 2/Zhong 892 cross and 90K SNP assay.

    **dong Liu, Zhonghu He, Ling Wu, Bin Bai, Weie Wen… in Theoretical and Applied Genetics (2016)

  17. No Access

    Article

    Development and validation of KASP assays for genes underpinning key economic traits in bread wheat

    We developed and validated a robust marker toolkit for high-throughput and cost-effective screening of a large number of functional genes in wheat.

    Awais Rasheed, Weie Wen, Fengmei Gao, Shengnan Zhai… in Theoretical and Applied Genetics (2016)

  18. No Access

    Article

    Cloning of TaSST genes associated with water soluble carbohydrate content in bread wheat stems and development of a functional marker

    We cloned TaSST genes, developed a gene-specific marker for TaSST - D1 , and identifi...

    Yan Dong, Yan Zhang, Yonggui **ao, Jun Yan, **dong Liu… in Theoretical and Applied Genetics (2016)

  19. No Access

    Article

    Genome-wide linkage map** of flour color-related traits and polyphenol oxidase activity in common wheat

    Fifty-six QTL for flour color-related traits and polyphenol oxidase activity were identified using a genome-wide linkage map** of data from a RIL population derived from a Gaocheng 8901/Zhoum...

    Shengnan Zhai, Zhonghu He, Weie Wen, Hui **… in Theoretical and Applied Genetics (2016)

  20. No Access

    Article

    TaTGW6-A1, an ortholog of rice TGW6, is associated with grain weight and yield in bread wheat

    The TGW6 gene encodes a novel indole-3-acetic acid-glucose hydrolase and plays a significant role in improving thousand grain weight (TGW) and yield in rice. In the current study, a TGW6 ortholog from bread wheat...

    Mamoona Hanif, Fengmei Gao, **dong Liu, Weie Wen, Yingjun Zhang… in Molecular Breeding (2015)

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