5 Result(s)
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Article
Vivian H. Gersuk
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Open AccessInterconnected lineage trajectories link conventional and natural killer (NK)-like exhausted CD8+ T cells beneficial in type 1 diabetes
Distinct Natural Killer (NK)-like CD57+ and PD-1+ CD8+ exhausted-like T cell populations (Tex) have both been linked to beneficial immunotherapy response in autoimmune type 1 diabetes (T1D) patients. The origins ...
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Open AccessThe transcriptional and phenotypic characteristics that define alveolar macrophage subsets in acute hypoxemic respiratory failure
The transcriptional and phenotypic characteristics that define alveolar monocyte and macrophage subsets in acute hypoxemic respiratory failure (AHRF) are poorly understood. Here, we apply CITE-seq (single-cell...
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Open AccessInflammatory bone marrow signaling in pediatric acute myeloid leukemia distinguishes patients with poor outcomes
High levels of the inflammatory cytokine IL-6 in the bone marrow are associated with poor outcomes in pediatric acute myeloid leukemia (pAML), but its etiology remains unknown. Using RNA-seq data from pre-trea...
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Presymptomatic diagnosis of postoperative infection and sepsis using gene expression signatures
Early accurate diagnosis of infection ± organ dysfunction (sepsis) remains a major challenge in clinical practice. Utilizing effective biomarkers to identify infection and impending organ dysfunction before th...
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Comparison of biomarkers for systemic juvenile idiopathic arthritis
Differentiation of systemic juvenile idiopathic arthritis (SJIA) fever from other childhood fevers is often delayed due to the lack of reliable, specific biomarkers. We hypothesized that PD-L1 expression is dy...
