22 Result(s)

Article

Mycobacterium vaccae Lysate Induces Anti-Allergic Immune Response In Vitro

Mycobacterium vaccae is a soil saprophyte which exerts anti-allergic properties. There are data that mechanism of action of M. vaccae when used in the treatment of human and animal allergic diseases is associated...

A. V. Strygin, P. P. Nesmiyanov… in Bulletin of Experimental Biology and Medic… (2020)

Article

Effects of a New Benzimidazole Derivative with Actoprotective Properties on Spermatogenic Epithelium of the Testes and Fertility of Male White Rats

The effects of a new derivative of benzimidazole (K-134) in doses of 5 and 50 mg/kg on the spermatogenesis and fertilizing ability of spermatozoa were studied on male rats. It was found that 2-month course tre...

L. I. Bugaeva, E. A. Kuzubova, V. I. Petrov… in Bulletin of Experimental Biology and Medic… (2020)

Article

Preclinical Toxicological Study of Release-Active Preparations for Prediction of Their Pharmacological Activity and Side Effects

We studied chronic toxicity of a few release-active preparations: Dietressa (release-active preparation of affinity-purified antibodies to type 1 cannabinoid receptor), Divasa (releaseactive preparation contai...

E. S. Zhavbert, E. I. Surkova… in Bulletin of Experimental Biology and Medic… (2016)

Article

Effects of a New Benzimidazole Derivative on Generative Function of Female Rats

The effects of a new thietanylbenzimidazole derivative (K-134) on estrous cycles, conception processes, and sexual behavior of female rats were studied. Two-week oral treatment with K-134 in doses of 5 and 50 ...

E. A. Kuzubova, L. I. Bugaeva… in Bulletin of Experimental Biology and Medic… (2015)

Article

Effects of Impaza on the Generative Function of Female Rats

The effects of impaza on ovulatory cycles, sexual behavior, and conception processes were studied in female rats. A two-week course of impaza in doses of 3 and 15 ml/kg did not affect alternation of estrous cy...

E. B. Lavrova, L. I. Bugaeva, E. A. Kuzubova… in Bulletin of Experimental Biology and Medic… (2015)

Article

Experimental Study of the Efficiency of Dietressa Preparation on Body Weight Reduction in Mice Feeding High-Fat Ration

We studied the efficiency of Dietressa on body weight reduction in C57Bl/6 male mice feeding standard high-fat ration (24%). After 5-month daily intragastric administration of Dietressa, body weight gain was t...

N. N. Gur’yanova, L. I. Bugaeva… in Bulletin of Experimental Biology and Medic… (2014)

Article

Antiaggregant Activity of a New Benzimidazole Derivative

Antiaggregant activity of a new tricyclic benzimidazole derivative, RU-891 compound, was studied on the model of ADP-induced platelet aggregation in vitro and intravascular platelet aggregation in vivo. We evalua...

A. F. Kucheryavenko, A. A. Spasov… in Bulletin of Experimental Biology and Medic… (2014)

Article

Experimental Study of the Effects of Dietressa, a New Weight-Reducing Drug

The capacity of a new drug containing ultra-low doses of antibodies to cannabinoid receptor type 1 (Dietressa) to reduce body weight gain in mice on a high-calorie diet was evaluated, possible mechanisms of dr...

I. A. Kheyfets, L. I. Bugaeva… in Bulletin of Experimental Biology and Medic… (2012)

Article

Some aspects of toxicological activity of kardosten after chronic 6-month administration to rats

Chronic treatment of rats with kardosten for 6 months had a positive effect on some ECG values and behavior without disordering the hepatorenal functions. All effects of the drug observed during a course of tr...

V. I. Petrov, L. I. Bugaeva, S. A. Lebedeva… in Bulletin of Experimental Biology and Medic… (2010)

Article

The Use of Ultralow Doses of Antibodies to C-Terminal Fragment of Angiotensin II AT1 Receptor (Kardos) in the Therapy of Arterial Hypertension

Kardos monotherapy allows attaining the target levels of systolic and diastolic blood pressure in patients with high-risk and very-high-risk hypertension. We demonstrated excellent tolerability of the preparat...

V. I. Petrov, S. V. Nedogoda, O. I. Epshtein… in Bulletin of Experimental Biology and Medic… (2009)

Article

Efficiency and Safety of Long-Term Artrofoon Treatment in Rheumatoid Arthritis

In patients with rheumatoid arthritis, prolongation of artrofoon therapy to 2 years led to maintenance of the positive clinical effect attained after 6-month treatment. Moreover, significant improvement was ob...

V. I. Petrov, A. R. Babaeva… in Bulletin of Experimental Biology and Medic… (2009)

Article

Effect of Combination of Anticytokine Preparations Anaferon and Artrofoon on Immune Inflammation in Rheumatoid Arthritis

Treatment with a combination of artrofoon and anaferon significantly reduced clinical and laboratory parameters of rheumatoid inflammation and significantly decreased the content of antiinflammatory cytokines ...

V. I. Petrov, A. R. Babaeva… in Bulletin of Experimental Biology and Medic… (2009)

Article

Pharmacodynamics of Kardos Administered as Monotherapy and in Combination with Hypothiazide and Enalapril in Grade I-II Arterial Hypertension

Therapy with kardos produced an antiihypertensve effect in patients with grade I-II arterial hypertension. This antiihypertensve effect was considerably potentiated, when kardos was administered in combination...

V. I. Petrov, O. I. Epshtein, S. A. Sergeeva… in Bulletin of Experimental Biology and Medic… (2009)

Article

Variability of neuronal damage and proportion of activities of NO synthase isoforms during cerebral ischemia/reperfusion in rats

We studied expression of endothelial and neuronal NO synthase isoforms and severity of ischemia/reperfusion-induced damage to neurons in different brain compartments in albino rats. The peculiarities of distri...

V. I. Petrov, V. B. Pisarev, E. A. Ponomarev… in Bulletin of Experimental Biology and Medic… (2007)

Article

Efficiency of Potentiated Antibodies to Tumor Necrosis Factor-α (Artrofoon) in the Therapy of Patients with Rheumatoid Arthritis

Antiinflammatory activity of a new preparation Artrofoon (antibodies against tumor necrosis factor-α in ultralow doses) and nonsteroid antiinflammatory drug diclofenac in patients with rheumatoid arthritis was...

V. I. Petrov, A. R. Babaeva… in Bulletin of Experimental Biology and Medic… (2003)

Article

Impaza and Sildenafil: Comparison of Clinical Effectiveness in Patients with Erectile Dysfunction

A blind, placebo-controlled, randomized trial showed clinical effectiveness of the preparation Impaza containing antibodies to endothelial NO synthase in ultralow doses. Impaza surpassed placebo, but was less ...

V. I. Petrov, A. S. Vekel'yan… in Bulletin of Experimental Biology and Medic… (2003)

Article

Antidepressant Activity of Aspartic Acid Derivatives

Antidepressant activity of N-phenyl(benzyl)amino derivatives of aspartic acid was studied on various experimental models of depression. IEM-1770 (30 mg/kg) and IEM-1944 (20 mg/kg) exhibited antidepressant acti...

V. I. Petrov, V. S. Sergeev… in Bulletin of Experimental Biology and Medic… (2001)

Article

Specific features in the behavior of rats with different genetic stability to stress

The effects of acute and chronic immobilization stress on the behavior of NISAG and outbred rats with different resistance to stress were evaluated. In the acute stress model, NISAG rats did not differ from st...

V. I. Petrov, I. A. Grigori'ev… in Bulletin of Experimental Biology and Medic… (1998)

Article

Role of different types of glutamate receptors in spatial memory in rats

V. I. Petrov, V. A. Sazhin, L. I. Deiko in Bulletin of Experimental Biology and Medicine (1992)

Article

Effect of ultrasound on adhesiveness ofEscherichia coli

Z. N. Kochemasova, V. I. Petrov… in Bulletin of Experimental Biology and Medic… (1983)