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Article
Open AccessP. gingivalis in oral-prostate axis exacerbates benign prostatic hyperplasia via IL-6/IL-6R pathway
Benign prostatic hyperplasia (BPH) is the most common disease in elderly men. There is increasing evidence that periodontitis increases the risk of BPH, but the specific mechanism remains unclear. This study a...
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Article
Prognosis difference between HER2-low and HER2-zero breast cancer patients: a systematic review and meta-analysis
HER2-low breast cancer (BC) is proposed to be a special population of patients with an immunohistochemistry (IHC) score of 1 + or 2 + and non-amplified in situ hybridization (ISH) results. The role and prognos...
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Article
Open AccessAlterations of gut microbiota diversity, composition and metabonomics in testosterone-induced benign prostatic hyperplasia rats
Studies had shown many diseases affect the stability of human microbiota, but how this relates to benign prostatic hyperplasia (BPH) has not been well understood. Hence, this study aimed to investigate the reg...
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Article
Open AccessComputational design of highly stable and soluble alcohol dehydrogenase for NADPH regeneration
Nicotinamide adenine dinucleotide phosphate (NADPH), as a well-known cofactor, is widely used in the most of enzymatic redox reactions, playing an important role in industrial catalysis. However, the absence o...
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Article
Open AccessDeterminants of successful guideline implementation: a national cross-sectional survey
CPGs are not uniformly successful in improving care and several instances of implementation failure have been reported. Performing a comprehensive assessment of the barriers and enablers is key to develo** a...
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Article
Open AccessChemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19: An evidence-based clinical practice guideline (updated version)
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of a rapidly spreading illness, coronavirus disease 2019 (COVID-19), affecting more than seventeen million people around the ...
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Article
Open AccessPerceived infection transmission routes, infection control practices, psychosocial changes, and management of COVID-19 infected healthcare workers in a tertiary acute care hospital in Wuhan: a cross-sectional survey
Many healthcare workers were infected by coronavirus disease 2019 (COVID-19) early in the epidemic posing a big challenge for epidemic control. Hence, this study aims to explore perceived infection routes, inf...
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Article
Open AccessA rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version)
In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province; and then named “2019 novel coronavirus (2019-nCoV)” by the World Health Organization (WHO) on 12 January 2020. For it is a ...
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Article
Improved inverse design method for thin-wall hollow profiled polymer extrusion die based on FEM-CFD simulations
Extrusion process has excellent capability in continuous manufactures with high production volume, low cost, and steady quality for very complex cross-sectional products. However, manufacturing a proper extrus...
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Article
Open AccessManagement of non-muscle-invasive bladder cancer: quality of clinical practice guidelines and variations in recommendations
Bladder cancer (BC) has become a major worldwide public health issue, especially non-muscle-invasive bladder cancer (NMIBC). A flood of related clinical practice guidelines (CPGs) have emerged; however, the qu...
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Article
Optimized Design Method for Profile Extrusion Die Based on NURBS Modeling
For optimization design of polymer extrusion dies, dimensional accuracy is critical to product quality of the extrudate. The extrusion dies used to be a regular geometrical profile, which is mostly composed by...
