5 Result(s)
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Article
Tilak Khanal
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Article
Open AccessAkt isoform-specific effects on thyroid cancer development and progression in a murine thyroid cancer model
The Akt family is comprised of three unique homologous proteins with isoform-specific effects, but isoform-specific in vivo data are limited in follicular thyroid cancer (FTC), a PI3 kinase-driven tumor. Prior...
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Progression and dormancy in metastatic thyroid cancer: concepts and clinical implications
Distant metastasis classically has been defined as a late-stage event in cancer progression. However, it has become clear that metastases also may occur early in the “lifetime” of a cancer and that they may re...
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Open AccessLoss of NR2E3 represses AHR by LSD1 reprogramming, is associated with poor prognosis in liver cancer
The aryl hydrocarbon receptor (AHR) plays crucial roles in inflammation, metabolic disorder, and cancer. However, the molecular mechanisms regulating AHR expression remain unknown. Here, we found that an orpha...
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Endosulfan induces COX-2 expression via NADPH oxidase and the ROS, MAPK, and Akt pathways
Endosulfan (1,4,5,6,7,7-hexachloro-8,9,10-trinorborn-5-en-2,3-ylenebismet-hylene) is correlated with endocrine disruption, reproductive, and immune dysfunctions. Recently, endosulfan was shown to have an effec...
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Role of metabolism by human intestinal microflora in geniposide-induced toxicity in HepG2 cells
Possible role of metabolism by the intestinal bacteria in geniposide-induced cytotoxicity was investigated in human hepatoma HepG2 cells. Initially, toxic effects of geniposide and its metabolite genipin were ...
