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Open AccessGenome bioinformatic analysis of nonsynonymous SNPs
Genome-wide association studies of common diseases for common, low penetrance causal variants are underway. A proportion of these will alter protein sequences, the most common of which is the non-synonymous si...
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Article
Janus kinases and signal transducers and activators of transcription: their roles in cytokine signaling, development and immunoregulation
Cytokines play a critical role in the normal development and function of the immune system. On the other hand, many rheumatologic diseases are characterized by poorly controlled responses to or dysregulated pr...
