17 Result(s)

Article

Determine TB-LAM point-of-care tuberculosis assay predicts poor outcomes in outpatients during their first year of antiretroviral therapy in South Africa

Determine TB-LAM is the first point-of-care test (POC) for HIV-associated tuberculosis (TB) and rapidly identifies TB in those at high-risk for short-term mortality. While the relationship between urine-LAM an...

Andrew D. Kerkhoff, Nicky Longley, Nicola Kelly, Anna Cross… in BMC Infectious Diseases (2020)

Article

Erratum to: Rapid urine-based screening for tuberculosis to reduce AIDS-related mortality in hospitalized patients in Africa (the STAMP trial): study protocol for a randomised controlled trial

Ankur Gupta-Wright, Katherine L. Fielding… in BMC Infectious Diseases (2016)

Article

Rapid urine-based screening for tuberculosis to reduce AIDS-related mortality in hospitalized patients in Africa (the STAMP trial): study protocol for a randomised controlled trial

HIV-associated tuberculosis (TB) co-infection remains an enormous burden to international public health. Post-mortem studies have highlighted the high proportion of HIV-positive adults admitted to hospital wit...

Ankur Gupta-Wright, Katherine L. Fielding… in BMC Infectious Diseases (2016)

Article

Diagnostic accuracy of the Xpert MTB/RIF assay for extrapulmonary and pulmonary tuberculosis when testing non-respiratory samples: a systematic review

Although the evidence base regarding the use of the Xpert MTB/RIF assay for diagnosis of pulmonary tuberculosis (TB) when testing respiratory samples is well established, the evidence base for its diagnostic a...

Laura Maynard-Smith, Natasha Larke, Jurgens A Peters… in BMC Infectious Diseases (2014)

Article

Resolution of anaemia in a cohort of HIV-infected patients with a high prevalence and incidence of tuberculosis receiving antiretroviral therapy in South Africa

Anaemia is frequently associated with both HIV-infection and HIV-related tuberculosis (TB) in antiretroviral therapy (ART)-naïve patients in sub-Saharan Africa and is strongly associated with poor prognosis. H...

Andrew D Kerkhoff, Robin Wood, Frank G Cobelens… in BMC Infectious Diseases (2014)

Article

Determine TB-LAM lateral flow urine antigen assay for HIV-associated tuberculosis: recommendations on the design and reporting of clinical studies

Detection of the Mycobacterium tuberculosis cell wall antigen lipoarabinomannan (LAM) in urine permits diagnoses of tuberculosis (TB) to be made in HIV-infected patients with advanced immunodeficiency. This can b...

Stephen D Lawn, Keertan Dheda, Andrew D Kerkhoff… in BMC Infectious Diseases (2013)

Article

The proportions of people living with HIV in low and middle-income countries who test tuberculin skin test positive using either a 5 mm or a 10 mm cut-off: a systematic review

A positive tuberculin skin test (TST) is often defined by skin induration of ≥10 mm in people who are HIV-seronegative. However, to increase sensitivity for detection of Mycobacterium tuberculosis infection in th...

Andrew D Kerkhoff, Ankur Gupta, Taraz Samandari, Stephen D Lawn in BMC Infectious Diseases (2013)

Article

Point-of-care detection of lipoarabinomannan (LAM) in urine for diagnosis of HIV-associated tuberculosis: a state of the art review

Detection of Mycobacterium tuberculosis antigens in urine is attractive as a potential means of diagnosing tuberculosis (TB) regardless of the anatomical site of disease. The most promising candidate antigen is t...

Stephen D Lawn in BMC Infectious Diseases (2012)

Article

Lipoarabinomannan in urine during tuberculosis treatment: association with host and pathogen factors and mycobacteriuria

Detection of lipoarabinomannan (LAM), a Mycobacterium tuberculosis (Mtb) cell wall antigen, is a potentially attractive diagnostic. However, the LAM-ELISA assay has demonstrated variable sensitivity in diagnosing...

Robin Wood, Kimberly Racow, Linda-Gail Bekker, Keren Middelkoop… in BMC Infectious Diseases (2012)

Article

Treatment outcomes in HIV-infected adolescents attending a community-based antiretroviral therapy clinic in South Africa

Very few data are available on treatment outcomes of adolescents living with HIV infection (whether perinatally acquired or sexually acquired) in sub-Saharan Africa. The present study therefore compared the tr...

Mweete D Nglazi, Katharina Kranzer, Pearl Holele, Richard Kaplan… in BMC Infectious Diseases (2012)

Article

Delays in starting antiretroviral therapy in patients with HIV-associated tuberculosis accessing non-integrated clinical services in a South African township

Delays in the initiation of antiretroviral therapy (ART) in patients with HIV-associated tuberculosis (TB) are associated with increased mortality risk. We examined the timing of ART among patients receiving c...

Stephen D Lawn, Lucy Campbell, Richard Kaplan, Francesca Little… in BMC Infectious Diseases (2011)

Article

Identification of losses to follow-up in a community-based antiretroviral therapy clinic in South Africa using a computerized pharmacy tracking system

High rates of loss to follow-up (LTFU) are undermining rapidly expanding antiretroviral treatment (ART) services in sub-Saharan Africa. The intelligent dispensing of ART (iDART) is an open-source electronic ph...

Mweete D Nglazi, Richard Kaplan, Robin Wood, Linda-Gail Bekker… in BMC Infectious Diseases (2010)

Article

Prevalence of HIV-associated ophthalmic disease among patients enrolling for antiretroviral treatment in India: A cross-sectional study

The ocular manifestations of HIV may lead to visual impairment or blindness. In India, patients typically initiate antiretroviral treatment (ART) with low CD4 cell counts when the risk of ocular complications ...

Sophia Pathai, Alaka Deshpande, Clare Gilbert, Stephen D Lawn in BMC Infectious Diseases (2009)

Article

Utility of CD4 cell counts for early prediction of virological failure during antiretroviral therapy in a resource-limited setting

Viral load monitoring is not available for the vast majority of patients receiving antiretroviral therapy in resource-limited settings. However, the practical utility of CD4 cell count measurements as an alter...

Motasim Badri, Stephen D Lawn, Robin Wood in BMC Infectious Diseases (2008)

Article

Utility of interferon-γ ELISPOT assay responses in highly tuberculosis-exposed patients with advanced HIV infection in South Africa

Interferon-gamma (IFN-γ) ELISPOT assays incorporating Mycobacterium tuberculosis-specific antigens are useful in the diagnosis of tuberculosis (TB) or latent infection. However, their utility in patients with adv...

Stephen D Lawn, Nonzwakazi Bangani, Monica Vogt… in BMC Infectious Diseases (2007)

Article

Plasma levels of soluble urokinase-type plasminogen activator receptor (suPAR) and early mortality risk among patients enrolling for antiretroviral treatment in South Africa

Serum concentrations of soluble urokinase-type plasminogen activator receptor (suPAR) have a strong independent association with HIV-1-related mortality. The practical utility of plasma suPAR in assessing shor...

Stephen D Lawn, Landon Myer, Nonzwakazi Bangani, Monica Vogt… in BMC Infectious Diseases (2007)

Article

CD4 cell count recovery among HIV-infected patients with very advanced immunodeficiency commencing antiretroviral treatment in sub-Saharan Africa

Patients accessing antiretroviral treatment (ART) programmes in sub-Saharan Africa frequently have very advanced immunodeficiency. Previous data suggest that such patients may have diminished capacity for CD4 ...

Stephen D Lawn, Landon Myer, Linda-Gail Bekker, Robin Wood in BMC Infectious Diseases (2006)