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Open AccessContinuous glucose monitoring during pregnancy in healthy mice
During pregnancy, metabolic adaptations occur to maintain the balance between maternal and foetal growth, including increased insulin secretion and decreased insulin sensitivity. When the body fails to adjust,...
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Article
Disentangling the role of TRPM4 in hippocampus-dependent plasticity and learning: an electrophysiological, behavioral and FMRI approach
Hippocampal long-term potentiation (LTP) has been extensively studied as a cellular model of learning and memory. Recently, we described a central function of the Transient Receptor Potential M4 (TRPM4) channe...
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Publisher Correction: A TRP channel trio mediates acute noxious heat sensing
In this Letter, the trace is missing in Fig. 1e. This error has been corrected online.
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Article
A TRP channel trio mediates acute noxious heat sensing
Three transient receptor potential channels (TRPA1, TRPV1 and TRPM3) mediate sensitivity to acute noxious heat in mice in a redundant system; mice lacking all three show severe deficits in heat sensing, wherea...
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Article
Open AccessSteviol glycosides enhance pancreatic beta-cell function and taste sensation by potentiation of TRPM5 channel activity
Steviol glycosides (SGs), such as stevioside and rebaudioside A, are natural, non-caloric sweet-tasting organic molecules, present in extracts of the scrub plant Stevia rebaudiana, which are widely used as sweete...
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Open AccessTRPM4-dependent post-synaptic depolarization is essential for the induction of NMDA receptor-dependent LTP in CA1 hippocampal neurons
TRPM4 is a calcium-activated but calcium-impermeable non-selective cation (CAN) channel. Previous studies have shown that TRPM4 is an important regulator of Ca2+-dependent changes in membrane potential in excitab...
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Open AccessVAMP7 regulates constitutive membrane incorporation of the cold-activated channel TRPM8
The cation channel TRPM8 plays a central role in the somatosensory system, as a key sensor of innocuously cold temperatures and cooling agents. Although increased functional expression of TRPM8 has been implic...
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Article
Open Access(18F)FDG-PET brain imaging during the micturition cycle in rats detects regions involved in bladder afferent signalling
This feasibility study established an experimental protocol to evaluate brain activation patterns using fluorodeoxyglucose positron emission tomography ((18F)FDG-PET) during volume-induced voiding and isovolum...