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Open AccessSafety, Tolerability, Pharmacokinetics and Initial Pharmacodynamics of a Subcommissural Organ-Spondin-Derived Peptide: A Randomized, Placebo-Controlled, Double-Blind, Single Ascending Dose First-in-Human Study
This randomized, double-blind, placebo-controlled study in healthy volunteers assessed the safety, tolerability, and pharmacokinetics of single ascending doses of intravenously administered NX210—a linear pept...
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Article
Open AccessLack of collagen XV is protective after ischemic stroke in mice
Collagens are key structural components of basement membranes, providing a scaffold for other components or adhering cells. Collagens and collagen-derived active fragments contribute to biological activities s...
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Article
Open AccessSulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke-induced neuroinflammation
Ischemic stroke is one of the main causes of death and disability worldwide. It is caused by the cessation of cerebral blood flow resulting in the insufficient delivery of glucose and oxygen to the neural tiss...
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Article
Early to Long-Term Alterations of CNS Barriers After Traumatic Brain Injury: Considerations for Drug Development
Traumatic brain injury (TBI) is one of the leading causes of death and disability, particularly amongst the young and the elderly. The functions of the blood-brain barrier (BBB) and blood-cerebrospinal fluid b...
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Article
Open AccessBexarotene targets autophagy and is protective against thromboembolic stroke in aged mice with tauopathy
Stroke is a highly debilitating, often fatal disorder for which current therapies are suitable for only a minor fraction of patients. Discovery of novel, effective therapies is hampered by the fact that advanc...
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Article
Open AccessErratum to: ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis
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Article
Open AccessADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis
A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) proteoglycanases are specialized in the degradation of chondroitin sulfate proteoglycans and participate in mechanisms mediating neuropla...
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Article
Open AccessADAMTS proteoglycanases in the physiological and pathological central nervous system
ADAMTS-1, -4, -5 and -9 belong to ‘a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)’ family and more precisely to the proteoglycanases subgroup based on their common ability to degrade c...