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Open AccessMorphological Tracing and Functional Identification of Monosynaptic Connections in the Brain: A Comprehensive Guide
Behavioral studies play a crucial role in unraveling the mechanisms underlying brain function. Recent advances in optogenetics, neuronal ty** and labeling, and circuit tracing have facilitated the dissection...
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Article
Open AccessTemporal-spatial Generation of Astrocytes in the Develo** Diencephalon
Astrocytes are the largest glial population in the mammalian brain. However, we have a minimal understanding of astrocyte development, especially fate specification in different regions of the brain. Through l...
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Novel Insight into Glial Biology and Diseases
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Pathological Networks Involving Dysmorphic Neurons in Type II Focal Cortical Dysplasia
Focal cortical dysplasia (FCD) is one of the most common causes of drug-resistant epilepsy. Dysmorphic neurons are the major histopathological feature of type II FCD, but their role in seizure genesis in FCD i...
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Article
cFos-ANAB: A cFos-based Web Tool for Exploring Activated Neurons and Associated Behaviors
cFos is one of the most widely-studied genes in the field of neuroscience. Currently, there is no systematic database focusing on cFos in neuroscience. We developed a curated database—cFos-ANAB—a cFos-based web t...
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Open AccessAnxiolytic Effect of Increased NREM Sleep after Acute Social Defeat Stress in Mice
Social defeat stress (SDS) plays a major role in the pathogenesis of psychiatric disorders like anxiety and depression. Sleep is generally considered to involve recovery of the brain from prior experience duri...
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Open AccessLysosomal Hydrolase Cathepsin D Non-proteolytically Modulates Dendritic Morphology in Drosophila
The main lysosomal protease cathepsin D (cathD) is essential for maintaining tissue homeostasis via its degradative function, and its loss leads to ceroid accumulation in the mammalian nervous system, which resul...
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Brain-wide Map** of Mono-synaptic Afferents to Different Cell Types in the Laterodorsal Tegmentum
The laterodorsal tegmentum (LDT) is a brain structure involved in distinct behaviors including arousal, reward, and innate fear. How environmental stimuli and top-down control from high-order sensory and limbi...
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Standardized Operational Protocol for Human Brain Banking in China
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Open AccessA Critical Time-Window for the Selective Induction of Hippocampal Memory Consolidation by a Brief Episode of Slow-Wave Sleep
Although extensively studied, the exact role of sleep in learning and memory is still not very clear. Sleep deprivation has been most frequently used to explore the effects of sleep on learning and memory, but...
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Anterograde Trans-Synaptic Tagging Mediated by Adeno-Associated Virus