10 Result(s)
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Seongsoo Lee
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Open AccessCREB5 promotes the proliferation and self-renewal ability of glioma stem cells
Glioblastoma multiforme (GBM) is the most fatal form of brain cancer in humans, with a dismal prognosis and a median overall survival rate of less than 15 months upon diagnosis. Glioma stem cells (GSCs), have ...
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Label-free multiplexed microtomography of endogenous subcellular dynamics using generalizable deep learning
Simultaneous imaging of various facets of intact biological systems across multiple spatiotemporal scales is a long-standing goal in biology and medicine, for which progress is hindered by limits of convention...
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Open AccessDetection of intracellular monosodium urate crystals in gout synovial fluid using optical diffraction tomography
Optical diffraction tomography (ODT) enables imaging of unlabeled intracellular components by measuring the three-dimensional (3D) refractive index (RI). We aimed to detect intracellular monosodium urate (MSU)...
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Open AccessThe overexpression of TDP-43 in astrocytes causes neurodegeneration via a PTP1B-mediated inflammatory response
Cytoplasmic inclusions of transactive response DNA binding protein of 43 kDa (TDP-43) in neurons and astrocytes are a feature of some neurodegenerative diseases, such as frontotemporal lobar degeneration with ...
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Open AccessAttenuation of synaptic toxicity and MARK4/PAR1-mediated Tau phosphorylation by methylene blue for Alzheimer’s disease treatment
Alzheimer’s disease (AD) is a neurodegenerative disease characterized by genotypic and phenotypic heterogeneity. Critical components of the two AD pathological pathways, Aβ-amyloidosis and Tauopathy, have been...
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Erratum to: Vision-Based Kidnap Recovery with SLAM for Home Cleaning Robots
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Phospho-dependent ubiquitination and degradation of PAR-1 regulates synaptic morphology and tau-mediated Aβ toxicity in Drosophila
The conserved kinases PAR-1/MARK are critically involved in processes such as asymmetric cell division, cell polarity and neuronal differentiation. Their deregulation has been implicated in diseases including ...
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Vision-Based Kidnap Recovery with SLAM for Home Cleaning Robots
Emerged as salient in the recent home appliance consumer market is a new generation of home cleaning robot featuring the capability of Simultaneous Localization and Map** (SLAM). SLAM allows a cleaning robot...
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On a component mode synthesis on multi-level and its application to dynamics analysis of vehicle system supported with spring-stiffness damper system
The component mode synthesis (CMS) method on multi-level, called as recursive component mode synthesis (RCMS) method, is implemented for the free vibration analysis of a vehicle system supported on damper-cont...
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The phosphoinositide phosphatase Sac1 is required for midline axon guidance
Sac1 phosphoinositide (PI) phosphatases are important regulators of PtdIns(4)P turnover at the ER, Golgi, and plasma membrane (PM) and are involved in diverse cellular processes including cytoskeletal organiza...
