3 Result(s)
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Article
Open AccessSuppression of heparan sulfation re-sensitizes YAP1-driven melanoma to MAPK pathway inhibitors
Accumulating evidence identifies non-genetic mechanisms substantially contributing to drug resistance in cancer patients. Preclinical and clinical data implicate the transcriptional co-activators YAP1 and its ...
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Article
Open AccessA comprehensive enhancer screen identifies TRAM2 as a key and novel mediator of YAP oncogenesis
Frequent activation of the co-transcriptional factor YAP is observed in a large number of solid tumors. Activated YAP associates with enhancer loci via TEAD4-DNA-binding protein and stimulates cancer aggressiv...
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Article
Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking
Hanno Glimm, Jan Korbel and colleagues present a computational framework called cis expression structural alteration map** (CESAM), which they use to identify somatic copy-number alterations affecting cis-regul...
