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    Establishment of the PAR-1 cortical gradient by the aPKC-PRBH circuit

    Cell polarity is the asymmetric compartmentalization of cellular components. An opposing gradient of partitioning-defective protein kinases, atypical protein kinase C (aPKC) and PAR-1, at the cell cortex guide...

    Ravikrishna Ramanujam, Ziyin Han, Zhen Zhang… in Nature Chemical Biology (2018)