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  1. No Access

    Article

    Check(point) yourself before you wreck yourself in tumors

    Expression of the inhibitory receptor PD-1 on regulatory T cells in the tumor microenvironment provides intrinsic stabilization, proliferation and metabolic rewiring signals to restrain tumor immunity.

    Jeong-Mi Lee, Peter T. Sage in Nature Immunology (2023)

  2. No Access

    Article

    Follicular regulatory T cells control humoral and allergic immunity by restraining early B cell responses

    Follicular regulatory T (TFR) cells have specialized roles in modulating follicular helper T (TFH) cell activation of B cells. However, the precise role of TFR cells in controlling antibody responses to foreign a...

    Rachel L. Clement, Joe Daccache, Mostafa T. Mohammed, Alos Diallo… in Nature Immunology (2019)

  3. No Access

    Article

    Suppression by TFR cells leads to durable and selective inhibition of B cell effector function

    Follicular regulatory T cells (TFR cells) inhibit follicular helper T cell (TFH cell)-mediated antibody production. Sharpe and colleagues show that TFR cells induce a distinct suppressive state in TFH cells and B...

    Peter T Sage, Noga Ron-Harel, Vikram R Juneja, Debattama R Sen… in Nature Immunology (2016)

  4. No Access

    Article

    Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability

    Regulatory T cells normally maintain high expression of the phosphatase PTEN. Turka and colleagues use conditional deletion of PTEN in regulatory T cells to show that it is critical for their function and stab...

    Alexandria Huynh, Michel DuPage, Bhavana Priyadharshini, Peter T Sage… in Nature Immunology (2015)

  5. No Access

    Article

    The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood

    Follicular regulatory T cells control humoral immune responses, but how these cells are in turn controlled has been unclear. Sharpe and colleagues demonstrate that signaling via PD-1 regulates number and funct...

    Peter T Sage, Loise M Francisco, Christopher V Carman, Arlene H Sharpe in Nature Immunology (2013)