13 Result(s)
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Article
Pankaj Sah
Neurobiology
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Article
Open AccessDiversity of interneurons in the lateral and basal amygdala
The basolateral amygdala (BLA) is a temporal lobe structure that contributes to a host of behaviors. In particular, it is a central player in learning about aversive events and thus assigning emotional valence...
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Author Correction: Hippocampus-driven feed-forward inhibition of the prefrontal cortex mediates relapse of extinguished fear
In the version of this article initially published, the traces in Fig. 1j and in Fig. 1k, right, were duplicated from the corresponding traces in Fig. 1c, bottom, and Fig. 1d, bottom right. The error has been ...
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Excitatory connections between the prelimbic and infralimbic medial prefrontal cortex show a role for the prelimbic cortex in fear extinction
We elucidated the intrinsic circuitry of the medial prefrontal cortex and its role in regulating fear extinction, using neuronal tracing and optogenetic stimulation in vitro and in vivo. We show that pyramidal...
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Open AccessThe nature and nurture of education
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Hippocampus-driven feed-forward inhibition of the prefrontal cortex mediates relapse of extinguished fear
The medial prefrontal cortex (mPFC) has been implicated in the extinction of emotional memories, including conditioned fear. We found that ventral hippocampal (vHPC) projections to the infralimbic (IL) cortex ...
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Open AccessIntegrating neuroscience and learning: now’s the time...
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Correction: Corrigendum: Regulating anxiety with extrasynaptic inhibition
Nat. Neurosci. 18, 1493–1500 (2015); published online 31 August 2015; corrected after print 5 October 2015 In the version of this article initially published, the grant number for U.R. was given as R01MH80006 ...
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Regulating anxiety with extrasynaptic inhibition
Less is known about the role of amygdala circuits in anxiety than in acute fear responses. In this study, the authors demonstrate that aversive experience induces anxiety in mice by regulating the excitability...
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Open AccessAuditory stimulation modulates amygdala network dynamics
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Imagined gait modulates neuronal network dynamics in the human pedunculopontine nucleus
The pedunculopontine nucleus (PPN) is a target for deep brain stimulation for the control of gait and postural disability, but its role in gait control is not understood. Here, using extracellular single-unit ...
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Open AccessThe C5a anaphylatoxin receptor CD88 is expressed in presynaptic terminals of hippocampal mossy fibres
In the periphery, C5a acts through the G-protein coupled receptor CD88 to enhance/maintain inflammatory responses. In the brain, CD88 can be expressed on astrocytes, microglia and neurons. Previous studies hav...
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SK channels regulate excitatory synaptic transmission and plasticity in the lateral amygdala
At glutamatergic synapses, calcium influx through NMDA receptors (NMDARs) is required for long-term potentiation (LTP); this is a proposed cellular mechanism underlying memory and learning. Here we show that i...
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Presynaptic long-term depression at a central glutamatergic synapse: a role for CaMKII
CaMKII is a calcium-activated kinase that is abundant in neurons and has been strongly implicated in memory and learning. Here we show that low-frequency stimulation of glutamatergic afferents in hippocampal s...
