5 Result(s)
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Article
Somatostatin neurons in the central amygdala mediate anxiety by disinhibition of the central sublenticular extended amygdala
Fear and anxiety are two defensive emotional states evoked by threats in the environment. Fear can be initiated by either imminent or future threats, but experimentally, it is typically studied as a phasic res...
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Article
Open AccessChanges in pallidal neural activity following long-term symptom improvement from botulinum toxin treatment in DYT6 dystonia: a case report
The globus pallidus internus is the main target for the treatment of dystonia by deep brain stimulation. Unfortunately, for some genetic etiologies, the therapeutic outcome of dystonia is less predictable. In ...
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Article
Open AccessLow-intensity ultrasound restores long-term potentiation and memory in senescent mice through pleiotropic mechanisms including NMDAR signaling
Advanced physiological aging is associated with impaired cognitive performance and the inability to induce long-term potentiation (LTP), an electrophysiological correlate of memory. Here, we demonstrate in the...
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Article
Open AccessA randomised, double-blind, sham-controlled trial of deep brain stimulation of the bed nucleus of the stria terminalis for treatment-resistant obsessive-compulsive disorder
Deep brain stimulation (DBS) is a promising treatment for severe, treatment-resistant obsessive-compulsive disorder (OCD). Here, nine participants (four females, mean age 47.9 ± 10.7 years) were implanted with...
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Open Access1,25-Dihydroxyvitamin D modulates L-type voltage-gated calcium channels in a subset of neurons in the develo** mouse prefrontal cortex
Schizophrenia has been associated with a range of genetic and environmental risk factors. Here we explored a link between two risk factors that converge on a shared neurobiological pathway. Recent genome-wide ...
