8 Result(s)
within
Article
Paco Hulpiau
-
Article
Open AccessFunctions of the RIP kinase family members in the skin
The receptor interacting protein kinases (RIPK) are a family of serine/threonine kinases that are involved in the integration of various stress signals. In response to several extracellular and/or intracellula...
-
Article
Open AccessNeutralization of Junín virus by single domain antibodies targeted against the nucleoprotein
The syndrome viral haemorrhagic fever (VHF) designates a broad range of diseases that are caused by different viruses including members of the family Arenaviridae. Prophylaxis for Argentine Haemorrhagic Fever (AH...
-
Article
Nanos genes and their role in development and beyond
The hallmark of Nanos proteins is their typical (CCHC)2 zinc finger motif (zf-nanos). Animals have one to four nanos genes. For example, the fruit fly and demosponge have only one nanos gene, zebrafish and humans...
-
Article
Metazoan evolution of the armadillo repeat superfamily
The superfamily of armadillo repeat proteins is a fascinating archetype of modular-binding proteins involved in various fundamental cellular processes, including cell–cell adhesion, cytoskeletal organization, ...
-
Article
MALT1 is not alone after all: identification of novel paracaspases
Paracaspases and metacaspases are two families of caspase-like proteins identified in 2000. Up until now paracaspases were considered a single gene family with one known non-metazoan paracaspase in the slime m...
-
Article
A bacterial glycosidase enables mannose-6-phosphate modification and improved cellular uptake of yeast-produced recombinant human lysosomal enzymes
Tiels et al. identify a bacterial glycosidase that facilitates improved modification of N-glycans on the Pompe disease enzyme α-glucosidase.
-
Article
Evolutionary functional analysis and molecular regulation of the ZEB transcription factors
ZEB1 and ZEB2, which are members of the ZEB family of transcription factors, play a pivotal role in the development of the vertebrate embryo. However, recent evidence shows that both proteins can also drive th...
-
Article
Open AccessText-mining assisted regulatory annotation
Decoding transcriptional regulatory networks and the genomic cis-regulatory logic implemented in their control nodes is a fundamental challenge in genome biology. High-throughput computational and experimental an...
