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Open AccessThe arid Andean plateau waterscapes and the lithium triangle: flamingos as flagships for conservation of high-altitude wetlands under pressure from mining development
The high Andean arid plateau extends through Peru, Argentina, Bolivia, and Chile. Within the desert matrix, basins contain wetlands that provide essential resources for human activity, and habitat for biodiver...
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Constitutive phosphorylation of the active Notch1 intracellular domain in chronic lymphocytic leukemia cells with NOTCH1 mutation
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A revised NOTCH1 mutation frequency still impacts survival while the allele burden predicts early progression in chronic lymphocytic leukemia
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Influence of the KDEL signal, DMSO and mannitol on the production of the recombinant antibody 14D9 by long-term Nicotiana tabacum cell suspension culture
We have established two transgenic cell suspension culture lines of Nicotiana tabacum that express the catalytic antibody 14D9 as a secretory product (sec-Ab) or as a KDEL-tagged product in the endoplasmic reticu...
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Open AccessIs extended resistance to the historical antiretroviral drugs & drug classes still a risk factor for HIV progression?
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Italian Consensus Statement on Management of HIV-Infected Individuals with Advanced Disease Naïve to Antiretroviral Therapy
Individuals with advanced HIV infection naïve to antiretroviral therapy represent a special population of patients frequently encountered in clinical practice. They are at high risk of disease progression and ...
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Open AccessRelationship between different types of non-adherence behaviour and virological response in unselected HIV-positive cohort
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Open AccessUsing the latest resistance score to predict etravirine (ETV) resistance in naïve and NNRTI-failing patients
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Open AccessLong-term efficacy of boosted and unboosted atazanavir-containing regimens: results from the SCOLTA Project
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Evidence of Dual Sexual Transmission of Multi-resistant HIV with Two Years Persistence of Resistance to NRTI and NNRTI: a Case Report
A case report of dual sexual transmission, with secondary transmission from naïve to naïve patient, of HIV harbouring K103N and L100I mutations, conferring full non-nucleoside reverse transcriptase inhibitor (...
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Observational Study on HIV-Infected Subjects Failing HAART Receiving Tenofovir Plus Didanosine as NRTI Backbone
We evaluated the efficacy of tenofovir (TDF) – and didanosine (ddI)-containing backbones in HIV-infected experienced subjects. We included in the study 245 subjects who started a TDF/ddI-containing HAART with ...
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Antitumor effects of non-replicative herpes simplex vectors expressing antiangiogenic proteins and thymidine kinase on Lewis lung carcinoma establishment and growth
There is growing evidence that combinations of antiangiogenic proteins with other antineoplastic treatments such as chemo- or radiotherapy and suicide genes-mediated tumor cytotoxicity lead to synergistic effe...
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HSV-1-mediated IL-1 receptor antagonist gene therapy ameliorates MOG35–55-induced experimental autoimmune encephalomyelitis in C57BL/6 mice
Primary proinflammatory cytokines, such as IL-1β, play a crucial pathogenic role in multiple sclerosis and its animal model experimental autoimmune encephalomyelitis (EAE), and may represent, therefore, a suitabl...
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Development and application of replication-incompetent HSV-1-based vectors
The replication-incompetent HSV-1-based vectors are herpesviruses in which genes that are ‘essential’ for viral replication have been either mutated or deleted. These deletions have substantially reduced their...
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Sanitary Monitoring Models for Wild Ungulate Stock Farms in Tuscany
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Effects of defective herpes simplex vectors expressing neurotrophic factors on the proliferation and differentiation of nervous cells in vivo
Neurotrophic factors (NTFs) are known to govern the processes involved in central nervous system cell proliferation and differentiation. Thus, they represent very attractive candidates for use in the study and...
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Genetically modified CD34+ cells as cellular vehicles for gene delivery into areas of angiogenesis in a rhesus model
To develop a cellular vehicle able to reach systemically disseminated areas of angiogenesis, we sought to exploit the natural tropism of circulating endothelial progenitor cells (EPCs). Primate CD34+ EPCs were ge...
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Replication-defective herpes simplex virus vectors for neurotrophic factor gene transfer in vitro and in vivo
We report here the construction and the use of two replication-defective herpes simplex virus vectors, SH FGF-2 and TH FGF-2, which efficiently transfer and express the cDNA for fibroblast-growth-factor-2 (FGF...
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The role of the peritoneal cavity in successful treatment of a murine lymphoma with chemotherapy and non-specific immunostimulation
The influence of the route of administration and treatment schedule of a yeast immunoadjuvant, Candida albicans (CA) on the degree of success achieved with an immunochemotherapy regimen in a virus-induced muri...
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Immunoadjuvant effects of Candida albicans and its cell wall fractions in a mouse lymphoma model
Chemical, ultrastructural, and immunoadjuvant properties of Candida albicans (CA) and of a number of its fractions have been characterized through the analysis of the antitumor activity of soluble and insolubl...