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    Tacrolimus (FK 506) biotransformation in primary rat hepatocytes depends on extracellular matrix geometry

    Established in vitro models for studies of hepatic drug biotransformation include the use of primary hepatocytes. In normal liver the space of Disse provides the possibility of bilateral attachment to extracel...

    A. Bader, E. Knop, K. H. W. Böker, O. Crome… in Naunyn-Schmiedeberg's Archives of Pharmaco… (1996)